Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies
Journal article published in 2021 by
Pedro M. Folegatti 
,
Amy Flaxman ,
Daniel Jenkin ,
Rebecca Makinson ,
Lucy Kingham-Page ,
Duncan Bellamy ,
Fernando Ramos Lopez ,
Jonathan Sheridan ,
Ian Poulton,
Jeremy Aboagye,
Nguyen Tran,
Celia Mitton,
Rachel Roberts,
Alison M. Lawrie,
Adrian V. S. Hill
and other authors.
,
Amy Flaxman ,
Daniel Jenkin ,
Rebecca Makinson ,
Lucy Kingham-Page ,
Duncan Bellamy ,
Fernando Ramos Lopez ,
Jonathan Sheridan ,
Ian Poulton,
Jeremy Aboagye,
Nguyen Tran,
Celia Mitton,
Rachel Roberts,
Alison M. Lawrie,
Adrian V. S. Hill
and other authors.
This paper is made freely available by the publisher.
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Abstract
Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.