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American Association for the Advancement of Science, Science, 6577(375), 2022

DOI: 10.1126/science.abi4343

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Mitochondria shed their outer membrane in response to infection-induced stress

Journal article published in 2022 by Xianhe Li ORCID, Julian Straub ORCID, Tânia Catarina Medeiros, Chahat Mehra ORCID, Fabian den Brave ORCID, Esra Peker, Ilian Atanassov ORCID, Katharina Stillger ORCID, Jonas Benjamin Michaelis ORCID, Emma Burbridge, Colin Adrain ORCID, Christian Münch ORCID, Jan Riemer ORCID, Thomas Becker ORCID, Lena F. Pernas ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Mitochondria shed their SPOTs Outer mitochondrial membrane (OMM) function is essential for cellular health. How mitochondria respond to naturally occurring OMM stress is unknown. Li et al . show that, upon infection with the human parasite Toxoplasma gondii , mitochondria shed large structures positive for OMM (SPOTs). SPOT formation required the parasite effector TgMAF1 and its interaction with the host mitochondrial receptor TOM70 and translocase SAM50. TOM70-dependent SPOT formation mediated a depletion of mitochondrial proteins and optimal parasite growth. SPOT-like structures also formed after OMM perturbations independently of infection. Thus, membrane remodeling is a feature of cellular responses to OMM stress that Toxoplasma hijacks during infection. —SMH