Estimating the main hydrodynamic features of real vegetated water bodies is crucial to assure a balance between their hydraulic conveyance and environmental quality. Riparian vegetation stands have a high impact on vegetated channels. The present work has the aim to integrate riparian vegetation’s reflectance indices and hydrodynamics of real vegetated water flows to assess the impact of riparian vegetation morphometry on bulk drag coefficients distribution along an abandoned vegetated drainage channel fully covered by 9–10 m high Arundo donax (commonly known as giant reed) stands, starting from flow average velocities measurements at 30 cross-sections identified along the channel. A map of riparian vegetation cover was obtained through digital processing of Unnamed Aerial Vehicle (UAV)-acquired multispectral images, which represent a fast way to observe riparian plants’ traits in hardly accessible areas such as vegetated water bodies in natural conditions. In this study, the portion of riparian plants effectively interacting with flow was expressed in terms of ground-based Leaf Area Index measurements (LAI), which easily related to UAV-based Normalized Difference Vegetation Index (NDVI). The comparative analysis between Arundo donax stands NDVI and LAI map enabled the analysis of the impact of UAV-acquired multispectral imagery on bulk drag predictions along the vegetated drainage channel.