The objective was to relate, through the theoretical-scientific reference, the Advanced Practice of Nursing, Primary Health Care and Leprosy in Brazil. Descriptive study, integrative review, with theoretical-scientific survey carried out by crossing the Health Sciences Descriptors: Advanced Practice Nursing, Primary Health Care and Leprosy; Boolean operators applied AND and OR. By the VHL, in the SciELO Virtual Library and in the LILACS Database, data collection date: march 2022. After applying the inclusion and exclusion criteria, 16 studies remained to be analyzed in the research. The discussion on the incorporation of Advanced Practice Nurses in Brazil and Latin America began in 2013 with the launch by the Pan American Health Organization of the resolution Human Resources for Health, expanding access to qualified health professionals in health systems based on Primary Health Care, for this research focusing on leprosy. This study achieved its objective, relating through the theoretical-scientific framework the Advanced Practice of Nursing, Primary Health Care (PHC) and Leprosy in Brazil, demonstrating that international experiences have irrevocable potential to improve the population's access to health services.