Published in
Royal Society of Chemistry, Chemical Science, 21(12), p. 7308-7323, 2021
DOI: 10.1039/d1sc01886h
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Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy
Journal article published in 2021 by
Mayra A. Marques 
,
Maicon Landim-Vieira ,
Adolfo H. Moraes ,
Bin Sun,
Jamie R. Johnston,
Karissa M. Dieseldorff Jones,
Elio A. Cino,
Michelle S. Parvatiyar,
Isela C. Valera,
Jerson L. Silva ,
Vitold E. Galkin,
P. Bryant Chase ,
Peter M. Kekenes-Huskey,
Guilherme A. P. de Oliveira ,
Jose Renato Pinto
,
Maicon Landim-Vieira ,
Adolfo H. Moraes ,
Bin Sun,
Jamie R. Johnston,
Karissa M. Dieseldorff Jones,
Elio A. Cino,
Michelle S. Parvatiyar,
Isela C. Valera,
Jerson L. Silva ,
Vitold E. Galkin,
P. Bryant Chase ,
Peter M. Kekenes-Huskey,
Guilherme A. P. de Oliveira ,
Jose Renato Pinto
This paper is made freely available by the publisher.
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Abstract
Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca2+-regulation of myocardial contraction.