Published in
American Association for the Advancement of Science, Science, 6565(374), 2021
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Comment on “Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment”
Journal article published in 2021 by
Tomislav Maricic 
,
Nelly Helmbrecht ,
Stephan Riesenberg ,
Dominik Macak,
Philipp Kanis ,
Martin Lackner,
Agrafena Daria Pugach-Matveeva,
Svante Pääbo
,
Nelly Helmbrecht ,
Stephan Riesenberg ,
Dominik Macak,
Philipp Kanis ,
Martin Lackner,
Agrafena Daria Pugach-Matveeva,
Svante Pääbo
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Abstract
Trujillo et al . (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, providing another plausible explanation for the effects observed.