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Springer Nature [academic journals on nature.com], British Journal of Cancer, 9(124), p. 1469-1474, 2021

DOI: 10.1038/s41416-020-01233-5

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Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment.

Journal article published in 2021 by Jayant S. Vaidya ORCID, Max Bulsara, Michael Baum, Frederik Wenz, Jeffrey S. Tobias, Samuele Massarut, Steffi Pigorsch, Michael Alvarado, Michael Douek, Christobel Saunders, Henrik L. Flyger, Norman R. Williams, Wolfgang Eiermann, Chris Brew-Graves, Ingrid Potyka and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

SummaryIn the randomised TARGIT-A trial, risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy was non-inferior to whole-breast external beam radiotherapy, for local recurrence. In the long-term, no difference was found in any breast cancer outcome, whereas there were fewer deaths from non-breast-cancer causes. TARGIT-IORT should be included in pre-operative consultations with eligible patients.