Published in
American Association for Cancer Research, Cancer Discovery, 7(12), p. 1615-1616, 2022
DOI: 10.1158/2159-8290.cd-22-0472
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IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk
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Abstract
Summary: In this issue, Hu and colleagues unveil that IFNα administration combined with anti–PD-1 therapy can potentiate murine and human CD8+ T-cell antitumor response in hepatocellular carcinoma, highlighting a novel therapeutic strategy for hepatocellular carcinoma. See related article by Hu et al., p. 1718 (6) .