Published in
Springer Nature [academic journals on nature.com], British Journal of Cancer, 4(125), p. 467-469, 2021
DOI: 10.1038/s41416-021-01285-1
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Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
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Abstract
SummaryEmerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.