ABSTRACT The recent interest in constructing high and robust wooden structures has stimulated the investigation of physical and mechanical properties as well as their correlation with other important parameters of the material of tropical species like the Vatairea sp., whose popular name is angelim-amargoso, used especially in roof structures with large spans. The Brazilian Standard for wood constructions recommends using linear models to correct or estimate the strength and/or stiffness of wood correlated with moisture content and also provides the classification of hardwoods according to their characteristic strength. However, because wood is a natural, heterogeneous, and anisotropic material, certain properties may not be affected by significant differences in moisture content. Therefore, in this study, the influence of moisture content on fifteen physical and mechanical properties of Vatairea sp. wood was investigated through its characterization. The tests were carried out on 12 specimens for each property and two groups: with the moisture content of 12% and at the fiber saturation point. The Anderson-Darling test was performed to verify the results’ normality and the analysis of variance (ANOVA) to analyze the influence of moisture content on these properties. In addition, the wood was classified according to the strength classes of the Brazilian Standard, and the strength and stiffness were estimated according to the linear models proposed by the same norm. The estimated results were compared with the experimental ones through the difference calculation and percentual error of the values. It was concluded that most properties were not affected by the moisture content, and the most significant errors obtained in the estimates were for properties that were significantly influenced by the moisture content.