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American Society for Microbiology, Journal of Virology, 24(95), 2021

DOI: 10.1128/jvi.00596-21

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Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

Journal article published in 2021 by Byron Shue, Abhilash I. Chiramel, Berati Cerikan, Thu-Hien To, Sonja Frölich ORCID, Stephen M. Pederson, Emily N. Kirby, Nicholas S. Eyre ORCID, Ralf F. W. Bartenschlager ORCID, Sonja M. Best, Michael R. Beard ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cellular factors are critical in all facets of viral lifecycles, where overlapping interactions between the virus and host can be exploited as possible avenues for the development of antiviral therapeutics. Using a genome-wide CRISPR knockout screening approach to identify novel cellular factors important for flavivirus replication we identified RACK1 as a pro-viral host factor for both mosquito- and tick-borne flaviviruses in addition to SARS-CoV-2.