Blood Cancer Discovery, p. OF1-OF3, 2022
DOI: 10.1158/2643-3230.bcd-22-0046
Full text: Unavailable
Summary: Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations.