Origanum elongatum L. is an endemic aromatic and medicinal plant. This work reports previous studies on O. elongatum concerning its taxonomy, botanical description, geographical distribution, bioactive compounds, toxicology, and biological effects. Chemical analyses showed that O. elongatum contains different chemical compounds, in particular volatile compounds. Pharmacological investigations showed that volatile compounds and extracts from O. elongatum exhibit different pharmacological properties, such as antibacterial, antifungal, antiviral, antioxidant, vasodilator, corrosion inhibitor, and hepatoprotective effects. Moreover, toxicological reports revealed the safety of this species. The pharmacological effects of O. elongatum could be correlated with the main compounds, which exhibit different pharmacological properties with numerous mechanism insights.