Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials
Journal article published in 2021 by
Kensuke Shima 
,
Inga Kaufhold,
Thomas Eder ,
Nadja Käding,
Nis Schmidt,
Iretiolu M. Ogunsulire,
René Deenen,
Karl Köhrer,
Dirk Friedrich ,
Sophie E. Isay,
Florian Grebien,
Matthias Klinger,
Barbara C. Richer,
Ulrich L. Günther ,
George S. Deepe
and other authors.
,
Inga Kaufhold,
Thomas Eder ,
Nadja Käding,
Nis Schmidt,
Iretiolu M. Ogunsulire,
René Deenen,
Karl Köhrer,
Dirk Friedrich ,
Sophie E. Isay,
Florian Grebien,
Matthias Klinger,
Barbara C. Richer,
Ulrich L. Günther ,
George S. Deepe
and other authors.
This paper is made freely available by the publisher.
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Abstract
The mitochondrion generates most of the ATP in eukaryotic cells, and its activity is used for controlling the intracellular growth of Chlamydia trachomatis . Furthermore, mitochondrial activity is tightly connected to host fatty acid synthesis that is indispensable for chlamydial membrane biogenesis.