Published in
American Society for Microbiology, Microbiology Spectrum, 2(10), 2022
DOI: 10.1128/spectrum.01480-21
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Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay
Journal article published in 2022 by
Luisa Galati,
Jean-Damien Combes,
Florence Le Calvez-Kelm 
,
Sandrine McKay-Chopin,
Nathalie Forey,
Mathis Ratel,
James McKay,
Tim Waterboer,
Lea Schroeder,
Gary Clifford,
Massimo Tommasino ,
Tarik Gheit
,
Sandrine McKay-Chopin,
Nathalie Forey,
Mathis Ratel,
James McKay,
Tim Waterboer,
Lea Schroeder,
Gary Clifford,
Massimo Tommasino ,
Tarik Gheit
This paper is made freely available by the publisher.
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Abstract
The validity of HPV ctDNA as a marker of HPV-driven cancers has been previously reported. Herein we validated an alternative to ddPCR for HPV16 ctDNA detection, using a bead-based HPV genotyping assay that offers the potential advantage of reducing the cost of clinical management due to the multiplex capability of the test, thus facilitating its use in clinical settings.