Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease

Ghosh, Auyon J.; Hobbs, Brian D.; Moll, Matthew; Saferali, Aabida; Boueiz, Adel; Yun, Jeong H.; Sciurba, Frank; Barwick, Lucas; Limper, Andrew H.; Flaherty, Kevin; Criner, Gerard; Brown, Kevin K.; Wise, Robert; Martinez, Fernando J.; Lomas, David; Castaldi, Peter J.; Carey, Vincent J.; DeMeo, Dawn L.; Cho, Michael H.; Silverman, Edwin K.; Hersh, Craig P.; Crapo, James D.; Make, Barry J.; Regan, Elizabeth A.; Beaty, Terri H.; El-Boueiz, Adel; Foreman, Marilyn G.; Hayden, Lystra P.; Hetmanski, Jacqueline; Hokanson, John E.; Kim, Wonji; Laird, Nan; Lange, Christoph; Lutz, Sharon M.; McDonald, Merry-Lynn; Prokopenko, Dmitry; Morrow, Jarrett; Qiao, Dandi; Sakornsakolpat, Phuwanat; Wan, Emily S.; Centeno, Juan Pablo; Charbonnier, Jean-Paul; Coxson, Harvey O.; Galban, Craig J.; Han, MeiLan K.; Hoffman, Eric A.; Humphries, Stephen; Jacobson, Francine L.; Judy, Philip F.; Kazerooni, Ella A.; Kluiber, Alex; Lynch, David A.; Nardelli, Pietro; Newell, John D.; Notary, Aleena; Oh, Andrea; Ross, James C.; Estepar, Raul San Jose; Schroeder, Joyce; Sieren, Jered; Stoel, Berend C.; Tschirren, Juerg; Van Beek, Edwin; van Ginneken, Bram; van Rikxoort, Eva; Sanchez-Ferrero, Gonzalo Vegas; Veitel, Lucas; Washko, George R.; Wilson, Carla G.; Jensen, Robert; Everett, Douglas; Crooks, Jim; Pratte, Katherine; Strand, Matt; Austin, Erin; Kinney, Gregory; Young, Kendra A.; Bhatt, Surya P.; Bon, Jessica; Diaz, Alejandro A.; Make, Barry; Murray, Susan; Regan, Elizabeth; Soler, Xavier; Bowler, Russell P.; Kechris, Katerina; Banaei-Kashani, Farnoush; Curtis, Jeffrey L.; Pernicano, Perry G.; Hanania, Nicola; Atik, Mustafa; Boriek, Aladin; Guntupalli, Kalpatha; Guy, Elizabeth; Parulekar, Amit; Hersh, Craig; Washko, George; Barr, R. Graham; Austin, John; D’Souza, Belinda; Thomashow, Byron; MacIntyre, Neil; McAdams, H. Page; Washington, Lacey; McEvoy, Charlene; Tashjian, Joseph; Brown, Robert; Hansel, Nadia N.; Horton, Karen; Lambert, Allison; Putcha, Nirupama; Casaburi, Richard; Adami, Alessandra; Budoff, Matthew; Fischer, Hans; Porszasz, Janos; Rossiter, Harry; Stringer, William; Sharafkhaneh, Amir; Lan, Charlie; Wendt, Christine; Bell, Brian; Kunisaki, Ken M.; Flenaugh, Eric L.; Gebrekristos, Hirut; Ponce, Mario; Terpenning, Silanath; Westney, Gloria; Rosiello, Richard; Pace, David; Ciccolella, David; Cordova, Francis; Dass, Chandra; D’Alonzo, Gilbert; Desai, Parag; Jacobs, Michael; Kelsen, Steven; Kim, Victor; Mamary, A. James; Marchetti, Nathaniel; Satti, Aditi; Shenoy, Kartik; Steiner, Robert M.; Swift, Alex; Swift, Irene; Vega-Sanchez, Maria Elena; Dransfield, Mark; Bailey, William; Iyer, Anand; Nath, Hrudaya; Wells, J. Michael; Conrad, Douglas; Yen, Andrew; Comellas, Alejandro P.; Hoth, Karin F.; Newell, John; Thompson, Brad; Kazerooni, Ella; Labaki, Wassim; Galban, Craig; Vummidi, Dharshan; Billings, Joanne; Begnaud, Abbie; Allen, Tadashi; Chandra, Divay; Weissfeld, Joel; Anzueto, Antonio; Adams, Sandra; Maselli-Caceres, Diego; Ruiz, Mario E.; Singh, Harjinder

Published in

American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 3(205), p. 313-323, 2022

DOI: 10.1164/rccm.202106-1404oc

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Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease

Journal article published in 2022 by Auyon J. Ghosh

, Brian D. Hobbs

, Matthew Moll, Aabida Saferali, Adel Boueiz, Jeong H. Yun

, Frank Sciurba, Lucas Barwick, Andrew H. Limper, Kevin Flaherty, Gerard Criner, Kevin K. Brown, Robert Wise

, Fernando J. Martinez, David Lomas

and other authors.

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Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease