Published in
American Society for Microbiology, Journal of Clinical Microbiology, 3(60), 2022
DOI: 10.1128/jcm.02245-21
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Impact of Ceftazidime-Avibactam Treatment in the Emergence of Novel KPC Variants in the ST307-Klebsiella pneumoniae High-Risk Clone and Consequences for Their Routine Detection
Journal article published in 2022 by
Marta Hernández-García 
,
Juan Antonio Castillo-Polo,
Desirèe Gijón Cordero,
Blanca Pérez-Viso,
María García-Castillo,
Javier Saez de la Fuente,
María Isabel Morosini,
Rafael Cantón ,
Patricia Ruiz-Garbajosa
,
Juan Antonio Castillo-Polo,
Desirèe Gijón Cordero,
Blanca Pérez-Viso,
María García-Castillo,
Javier Saez de la Fuente,
María Isabel Morosini,
Rafael Cantón ,
Patricia Ruiz-Garbajosa
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Abstract
The emergence of Klebsiella pneumoniae isolates carrying novel bla KPC variants conferring ceftazidime-avibactam (CAZ/AVI) resistance is being increasingly reported. We evaluated the accuracy of phenotypic methods commonly used in routine clinical laboratories in the detection of novel K. pneumoniae carbapenemase (KPC) enzymes.