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American Society for Microbiology, mBio, 4(13), 2022

DOI: 10.1128/mbio.01904-22

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Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

Journal article published in 2022 by Madeline R. Barron ORCID, Kelly L. Sovacool ORCID, Lisa Abernathy-Close ORCID, Kimberly C. Vendrov ORCID, Alexandra K. Standke, Ingrid L. Bergin, Patrick D. Schloss ORCID, Vincent B. Young ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Patients with inflammatory bowel disease (IBD) have an increased risk of developing C. difficile infection (CDI), even in the absence of antibiotic treatment. Yet, mechanisms regulating C. difficile colonization in IBD patients remain unclear.