Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant
Journal article published in 2021 by
Jhansi L. Leslie 
,
Matthew L. Jenior ,
Kimberly C. Vendrov ,
Alexandra K. Standke ,
Madeline R. Barron ,
Tricia J. O’Brien,
Lavinia Unverdorben,
Pariyamon Thaprawat ,
Ingrid L. Bergin,
Patrick D. Schloss ,
Vincent B. Young
,
Matthew L. Jenior ,
Kimberly C. Vendrov ,
Alexandra K. Standke ,
Madeline R. Barron ,
Tricia J. O’Brien,
Lavinia Unverdorben,
Pariyamon Thaprawat ,
Ingrid L. Bergin,
Patrick D. Schloss ,
Vincent B. Young
This paper is made freely available by the publisher.
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Abstract
Antibiotic-associated colitis is often caused by infection with the bacterium Clostridioides difficile . In this study, we found that reduction of the amino acid glycine by precolonization with a less virulent strain of C. difficile is sufficient to decrease germination of a second strain.