Published in

American Society for Microbiology, mBio, 3(12), 2021

DOI: 10.1128/mbio.02733-20

Links

Tools

Export citation

Search in Google Scholar

Intestinal Inflammation and Altered Gut Microbiota Associated with Inflammatory Bowel Disease Render Mice Susceptible to Clostridioides difficile Colonization and Infection

Journal article published in 2021 by Lisa Abernathy-Close ORCID, Madeline R. Barron ORCID, James M. George, Michael G. Dieterle ORCID, Kimberly C. Vendrov ORCID, Ingrid L. Bergin, Vincent B. Young ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

The incidence of C. difficile infection (CDI) has increased significantly among patients with IBD, independently of antibiotic use, yet the relationship between IBD and increased risk for CDI remains to be understood. Our study sought to describe and utilize an antibiotic-independent mouse model to specifically explore the relationship between the IBD-associated gut and susceptibility to C. difficile colonization and CDI development.