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American Society for Microbiology, mBio, 2(12), 2021

DOI: 10.1128/mbio.02823-20

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Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

Journal article published in 2021 by Arun Dhillon, Justin C. Deme, Emily Furlong, Dorina Roem, Ilse Jongerius ORCID, Steven Johnson, Susan M. Lea ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The structure of a 10-kDa protein complex is one of the smallest to be determined using cryo-electron microscopy at high resolution. The structure reveals that C1-INH is sequestered in an inactivated state by burial of the reactive center loop in Vag8.