X-ray imaging plays a crucial role in the confirmation of COVID-19 pneumonia. Chest X-ray radiography and CT are two major imaging techniques that are currently adopted in the diagnosis of COVID-19 pneumonia. However, dual-energy subtraction radiography is hardly discussed as potential COVID-19 imaging application. More advanced X-ray radiography equipment often supports dual-energy subtraction X-ray radiography. Dual-energy subtraction radiography enables the calculation of pseudo-radiographs, in which bones are removed and only soft-tissues are highlighted. In this commentary, the author would like to draw the attention to the potential use of dual-energy subtraction X-ray radiography (i.e. soft-tissue pseudo-radiography) for the assessment and the longitudinal follow-up of COVID-19 pneumonia.