The aim of this study was to describe weekly acute workload (wAW), chronic workload (wCW), acute: chronic workload ratio (wACWR), training monotony (wTM), and training strain (wTS) variations over a full season across playing positions. Twenty-one professional soccer players were daily monitored during 48 consecutive weeks. Total distance, sprint total distance (STD), high-speed running distance (HSRd), maximum speed, number of the repeated sprints, and body load (BL) were obtained during training and matches using a Wearable Inertial Measurement Unit. The wAW was determined for each external load measure. The wCW, wACWR, and wTM were calculated based on BL metric. Higher values of weekly STD were observed in lateral defenders/wingers (LDW) compared to central defenders/forwards (CDF) (p = 0.009; ES = Large) and midfielders (MDF) (p = 0.034; ES = Large). Additionally, weekly HSRd was higher in LDW vs. CDF (p = 0.016; ES = Large) and MDF (p = 0.011; ES = Large). The CDF presented a lower weekly number of repeated sprints than LDW (p = 0.021; ES = Large). In conclusion, weekly external load metrics were position-dependent over the season. Moreover, LDW a presented greater weekly STD, HSRd, and number of repeated sprints compared to other positions.