Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis
Journal article published in 2022 by
Joshua M. Thiede,
Nicholas A. Dillon 
,
Michael D. Howe,
Ranee Aflakpui,
Samuel J. Modlin ,
Sven E. Hoffner,
Faramarz Valafar ,
Yusuke Minato,
Anthony D. Baughn
,
Michael D. Howe,
Ranee Aflakpui,
Samuel J. Modlin ,
Sven E. Hoffner,
Faramarz Valafar ,
Yusuke Minato,
Anthony D. Baughn
This paper is made freely available by the publisher.
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Abstract
For decades, pyrazinamide has served as a cornerstone of tuberculosis therapy. Unlike any other antitubercular drug, pyrazinamide requires an acidic environment to exert its action.