Introduction: Acute ischemic stroke (AIS) patients transferred directly to the interventional suite can undergo flat-panel CT (FPCT) to bypass multidetector CT (MDCT) and eliminate delays to reperfusion therapy. However, the diagnostic adequacy of FPCT needs to be corroborated prior to eliminating MDCT from stroke care pathways. CT perfusion (CTP) maps played an important role in assessing infarcted vs. hypoperfused cerebral tissue in the 6-24 hour time window in the DAWN and DEFUSE-3 trials. We evaluated the diagnostic accuracy of FPCTP to identify infarcted vs. hypoperfused tissue using MDCTP as a reference. Materials and Methods: Between Oct. 19 and Nov. 21, 16 AIS patients at a tertiary urban hospital underwent FPCT and FPCTP. IRB approval and informed written consent was obtained. Ten patients underwent CTP in the ED. FPCTP was obtained using a Siemens Artis Q Biplane system. Data was post-processed on a separate prototype workstation, allowing visualization of ten 3D volumes in different phases of contrast enhancement (colored), and perfusion maps (CBF, CBV, MTT, TTP, T _max , and TTD) (Figure 1). The CBF and T _max , volumes have been further processed to generate color-coded hypoperfusion and core maps. Results: Eight FPCTP acquisitions were excluded due to technical problems, no available CTP, or severe motion artifacts. The infarcted and hypoperfused regions identified on FPCTP qualitatively agree with the regions identified on MDCTP. The time between CTP and FPCTP scans was a mean of 1h 2min (± 34min, 40- 2h30min). Three patients were under GA, the remaining 5 patients were scanned under moderate sedation. Three patients received IV-rtPA. Conclusion: FPCTP can be acquired to generate CBF, CBV, MTT, TTP, T _max , and TTD maps in the interventional suite, potentially bypassing MDCTP and eliminating delays to reperfusion therapy. Quantitative results require advanced post-processing, particularly for artifact mitigation. The study is limited by the small sample size.