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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(65), 2021

DOI: 10.1128/aac.02344-20

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Efficacy and Associated Drug Exposures of Isavuconazole and Fluconazole in an Experimental Model of Coccidioidomycosis

Journal article published in 2021 by Laura L. Kovanda ORCID, Gabriele Sass, Marife Martinez, Karl V. Clemons, Hasan Nazik, Therese M. Kitt, Nathan Wiederhold ORCID, William W. Hope ORCID, David A. Stevens
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Coccidioides spp. are important pathogens in regions where they are endemic, and new treatment options are needed. Here, isavuconazonium sulfate (ISAVUSULF) and fluconazole (FLU) were evaluated in experimental disseminated coccidioidomycosis to characterize drug exposures associated with efficacy. Broth macrodilution was performed on Coccidioides isolates to measure minimal effective concentrations (MEC) and minimal fungicidal concentrations (MFC).