Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial

del Mar Castellanos Rodrigo, Maria; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Wollboldt C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]van Sloten I.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Golsari A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Alegiani A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Beck C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Choe Cu; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Voget D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hoppe J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schröder J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Rozanski M.; van Sloten, Isabelle; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Nave Ah; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Göhler J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Herm J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Jungehülsing J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lückl J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kröber Jm; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schurig J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Koehler L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schlemm L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Knops M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Roennefarth M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ipsen N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Harmel P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bathe Peters R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Fleischmann R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ganeshan R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Geran R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hellwig S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schmidt S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Tütüncü S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Krause T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gramse V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Röther J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Michels P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Michalski D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pelz J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schulz A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hobohm C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Weise C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Weise G.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Orthgieß J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pomrehn K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Wegscheider M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Mueller Ak; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hennerici M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Griebe M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Alonso A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Filipov A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Marzina A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Anders B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bähr C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hoyer C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schwarzbach C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Weber C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hornberger E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Zeiner P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pledl Hw; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Klockziem M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Stuermlinger M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Wittayer M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Wolf M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Meyer N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Eisele P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Steinert S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sauer T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Held V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ringleb P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Nagel S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Veltkamp R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schwarting S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schwarz A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gumbinger C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hametner C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Ziemann U.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Amiri H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Purrucker J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ciatipis M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Menn O.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schieber S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kessler T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Zegarac V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Reiff T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Panitz V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Singer O.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Foerch C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lauer A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Männer A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Seiler A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Guerzoglu D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schäfer Jh; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Filipski K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]de Morales Nr; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lorenz M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]von Weitzel P.; Zeiner, Pia; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kurka N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pfeilschifter W.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dziewas R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Minnerup J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Albiker C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ritter M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Seidel M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dittrich R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kallmünzer B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bobinger T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Madzar D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Stark D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sembill J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Macha K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Winder K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Breuer L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Yperzeele L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Koehrmann M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Spruegel M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gerner S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kraft P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Mackenrodt D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kleinschnitz C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Younan N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Elhfnawy A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Heinen F.; Ziemann, Ulf; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gunreben I.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Poli S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gaenslen A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]de Hollander I.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schlak D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Haertig F.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Russo F.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Richter H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ebner M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ribitsch M.; Zegarac, Vesna; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Weimar C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Chen Hc; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Althaus K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Neugebauer H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Jüttler E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Meier J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Stösser S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Puetz V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bodechtel U.; de Morales, Noelia Ruiz; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ostergaard L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Møller A.; von Weitzel, Paul; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Damgaard D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dupont Kh; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Poulsen M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hjort N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Harbo T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Marstrand J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hansen A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Christensen H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Aegidius K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Jeppesen L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Yger M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Meden P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Rosenbaum S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Iversen H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Zuber M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hansen J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Michelsen L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Truelsen T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Modrau B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Wolff V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vestergaard K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Yalo B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Oppel L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sygehus A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Aalborg S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Swinnen B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Smets I.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Demeestere J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dobbels L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Brouns R.; Yperzeele, Laetita; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]De Smedt A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]DeKeyser J.; Cheng, Bastian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Van Hooff Rj; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Peeters A.; Boutitie, Florent; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dusart A.; Nickel, Alina; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Etexberria A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Wolf M.; Wouters, Anke; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hanseeuw B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]London F.; Younan, Nadia; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Leempoel J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hohenbichler K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Maqueda V.; Ebinger, Martin; de Hollander, Isabel; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Laloux P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]De Coene B.; Endres, Matthias; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]De Maeseneire C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Turine G.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vandermeeren Y.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]De Klippel N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Willems C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Soors P.; Nighoghossian, Norbert; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hermans S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hemelsoet D.; Thomalla, Götz; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]de la Ossa Np; Pedraza, Salvador; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Desfontaines P.; Gerloff, Christian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vanacker P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Rutgers M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Druart C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Peeters D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bruneel B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vancaester E.; Fiehler, Jens; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vanhee F.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Meersman G.; Voget, Dieke; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bourgeois P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vanderdonckt P.; Schröder, Julian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Benoit A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Derex L.; Rozanski, Michal; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Mechthouff L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Berhoune N.; Wollboldt, Christian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ritzenthaler T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Amarenco P.; Galinovic, Ivana; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hobeanu C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gancedo Em; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Calvet D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ladoux A.; Puig, Josep; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Machet A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]van den Berg L.; Schurig, Johannes; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]van den Berg S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lamy C.; Schlemm, Ludwig; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Zonneveld T.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Mellerio C.; Roennefarth, Maria; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Oppenheim C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bodiguel E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Turc G.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Birchenall J.; Thijs, Vincent; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Legrand L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Morin L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Edjali Goujon M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]Wollenweber F.; Cho, Tae-Hee; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Naggara O.; Schmidt, Sein; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Raphaelle S.; Tütüncü, Serdar; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Godon Hardy S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Domigo V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators and administrative staff are as follows:]von Schrader J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Guiraud V.; Röther, Joachim; Yger, Marion; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Samson Y.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Leger A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Rosso C.; Pelz, Johann; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Crozier S.; Zuber, Mathieu; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Deltour S.; Simonsen, Claus Z.; Schulz, Andreas; Lemmens, Robin; Fiebach, Jochen B.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sibon I.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Renou P.; Weise, Christopher; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sagnier S.; Weise, Gesa; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Tamazyan R.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Rodier G.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Morel N.; Pomrehn, Katrin; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Felix S.; Wegscheider, Mirko; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vadot W.; Yalo, Bertrand; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Aniculaesei A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bindila D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Quenardelle V.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Landrault E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Breynaert L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Cakmak S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Peysson S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Viguier A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lebely C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Raposo N.; Schwarzbach, Christopher; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vallet Ae; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vallet P.; Weber, Claudia; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Brugirard S.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Cheripelli B.; Pledl, Hans-Werner; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kalladka D.; Golsari, Amir; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Moreton F.; Alegiani, Anna; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dani K.; Stuermlinger, Markus; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Tawil Se; Beck, Christoph; Wittayer, Matthias; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ramachandran S.; Muir, Keith W.; Choe, Chi-Un; Wolf, Marc; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Huang X.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Warburton E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Evans N.; Hoppe, Julia; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Perry R.; Steinert, Susanne; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Patel B.; Sauer, Tamara; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Cloud G.; Mundiyanapurath, Sibu; Nave, Alexander H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pereira A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Moynihan B.; Ringleb, Peter; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lovelock C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Choy L.; Göhler, Jos; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Khan U.; Veltkamp, Roland; Herm, Juliane; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Roffe C.; Schwarting, Sönke; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Tyrell P.; Jungehülsing, Jan; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Smith C.; Schwarz, Alexander; Lückl, Janos; van Eendenburg, Cecile; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dixit A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Louw S.; Kröber, Jan M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Broughton D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Shetty A.; Koehler, Luzie; Purrucker, Jan; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Appleton J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sprigg N.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Acosta Br; Knops, Michael; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Leal Js; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Izaga Mt; Schieber, Simon; Ipsen, Nils; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Guillamon Ob; de la Ossa, Natalia Pérez; Harmel, Peter; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Arenillas J.; Reiff, Tilman; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Calleja A.; Bathe-Peters, Rouven; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Cortijo E.; Fleischmann, Robert; Singer, Oliver; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Mulero P.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Garrido A.; Ganeshan, Ramanan; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Martinez A.; Geran, Rohat; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Esperón Cg; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Guerrero C.; Hellwig, Simon; Seiler, Alexander; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Carrera D.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vilas D.; Schäfer, Jan H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lopez Cancio E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Palomeras E.; Krause, Thomas; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Lucente G.; Gramse, Verena; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gomis M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Isern I.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Becerra Jl; Pfeilschifter, Waltraud; Michels, Peter; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Vicente Jh; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sánchez J.; Michalski, Dominik; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Dorado L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Grau L.; Ritter, Martin; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ispierto L.; Hobohm, Carsten; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Prats L.; Seidel, Matthias; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Almendrote M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Hernández M.; Orthgieß, Johannes; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Jimenez M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Sánchez Ml; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Torne Mm; Stark, David; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Presas S.; Mueller, Anne K.; Sembill, Jochen; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Ustrell X.; Hennerici, Michael; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pellisé A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Navalpotro I.; Winder, Klemens; Griebe, Martin; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Luna A.; van den Berg, Lucie; Alonso, Angelika; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schonewille W.; van den Berg, Sophie; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Nederkoorn P.; Filipov, Alexandra; Spruegel, Maximilian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Majoie C.; Marzina, Annika; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Remmers M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Fazekas F.; Anders, Bettina; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pichler A.; Bähr, Christian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Fandler S.; Zonneveld, Thomas; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gattringer T.; Hoyer, Carolin; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Mutzenbach J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Weber J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Höfner E.; Poli, Sven; Hornberger, Eva; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kohlfürst H.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Weinstich K.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kellert L.; Klockziem, Matti; Schlak, Dennis; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Opherk C.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Klein M.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Pierskalla A.; Russo, Francesca; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Harloff A.; Meyer, Nadja; Richter, Hardy; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bardutzky J.; Eisele, Philipp; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Buggle F.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kollmar R.; Ribitsch, Martin; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Schill J.; Wolf, Martin; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Löbbe Am; Held, Valentin; von Schrader, Jörg; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Moulin T.; Weimar, Christian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bouamra B.; Nagel, Simon; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bonnet L.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Touzé E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bonnet Al; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Touze E.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Cogez J.; Gumbinger, Christoph; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Li L.; Hametner, Christian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Guettier S.; Stösser, Sebastian; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Kar A.; Amiri, Hemasse; Puetz, Volker; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Geraghty O.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Bojaryn U.; Ciatipis, Mareva; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Nallasivan A.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gonzales Mb; Menn, Oliver; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Tembl J.; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Gorriz D.; Poulsen, Marika; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Oberndorfer S.; Kessler, Tobias; [Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:]Prohaska E.; Panitz, Verena; Foerch, Christian; Lauer, Arne; Th, Cho; Cz, Simonsen; Männer, Anika; Follows:, Collective: WAKE-Up (Efficacy and Safety of Mri-Based Thrombolysis inWake-Up Stroke Trial) investigators administrative staff are as; Guerzoglu, Damla; Rosenbaum, Sverre; Filipski, Katharina; Lorenz, Matthias; Truelsen, Thomas; Kurka, Natalia; Vestergaard, Karsten; Dziewas, Rainer; Sygehus, Aalborg; Minnerup, Jens; Swinnen, Bart; Albiker, Christian; Smets, Ide; Dittrich, Ralf; Kallmünzer, Bernd; Bobinger, Tobias; Madzar, Dominik; Van Hooff, Robbert-Jan; Jb, Fiebach; Peeters, Andre; Macha, Kosmas; Breuer, Lorenz; Koehrmann, Martin; Gerner, Stefan; Kraft, Peter; Mackenrodt, Daniel; Kleinschnitz, Christoph; Turine, Gaetane; Elhfnawy, Ahmed; Vandermeeren, Yves; Heinen, Florian; Willems, Chris; Gunreben, Ignaz; Soors, Peter; Gaenslen, Alexandra; Haertig, Florian; Vanacker, Peter; Rutgers, Matthieu; Ebner, Matthias; Peeters, Dirk; Vancaester, Evelien; Vanhee, Frederik; Chen, Hsin-Chieh; Althaus, Katharina; Neugebauer, Hermann; Vanderdonckt, Patrick; Jüttler, Eric; Meier, Julia; Ritzenthaler, Thomas; Bodechtel, Ulf; Ostergaard, Leif; Møller, Anette; Damgaard, Dorte; Dupont, Kristina Hougaard; Hjort, Niels; Rodriguez-Regent, Christine; Harbo, Thomas; Turc, Guillaume; Marstrand, Jacob; Hansen, Andreas; Christensen, Hanne; Aegidius, Karen; Raphaelle, Soulliard; Jeppesen, Lise; Meden, Per; Samson, Yves; Iversen, Helle; Hansen, Jakob; Rosso, Charlotte; Michelsen, Lene; Modrau, Boris; Sibon, Igor; Oppel, Lorenz; Renou, Pauline; Aalborg, Syd; Sagnier, Sharmilla; Tamazyan, Ruben; Demeestere, Jelle; Rodier, Gilles; Dobbels, Laurens; Brouns, Raf; Vadot, Wilfried; De Smedt, Ann; Wolff, Valerie; DeKeyser, Jacques; Quenardelle, Veronique; Dusart, Anne; Etexberria, Ana; Hanseeuw, Bernard; London, Frederic; Peysson, Stéphane; Leempoel, Jonathan; Viguier, Alain; Hohenbichler, Katharina; Raposo, Nicolas; Maqueda, Vicky; Vallet, Anne-Evelyne; Laloux, Patrice; Vallet, Pauline; Kw, Muir; De Coene, Beatrijs; De Maeseneire, Charlotte; De Klippel, Nina; Tawil, Salwa El; Ramachandran, Sankaranarayanan; Hermans, Sylvia; Warburton, Elisabeth; Hemelsoet, Dimitri; Perry, Richard; Desfontaines, Philippe; Pereira, Anthony; Druart, Charlotte; Baronnet-Chauvet, Flore; Bruneel, Bart; Roffe, Christine; Tyrell, Pippa; Meersman, Guy; Smith, Craig; Bourgeois, Paul; Benoit, Amandine; Derex, Laurent; Shetty, Ashit; Mechthouff, Laura; Sprigg, Nikola; Berhoune, Nadia; Rodrigo, Mar Castellanos; Amarenco, Pierre; Hobeanu, Cristina; Gancedo, Elena Meseguer; Calvet, David; Ladoux, Alexandre; Machet, Alexandre; Lamy, Catherine; Mellerio, Charles; Oppenheim, Catherine; Blanc-Lasserre, Karine; Bodiguel, Eric; Vilas, Dolores; Birchenall, Julia; Legrand, Laurence; Morin, Ludovic; Edjali-Goujon, Myriam; Vicente, Jose Hervas; Naggara, Oliver; Sánchez, Josep; Godon-Hardy, Sylvie; Domigo, Valérie; Guiraud, Vincent; Prats, Luis; Leger, Anne; Sánchez, Manuel Lozano; Crozier, Sophie; Torne, Monica Millán; Deltour, Sandrine; Presas, Silvia; Ustrell, Xavier; Pellisé, Anna; Schonewille, Wouter; Morel, Nathalie; Felix, Sandra; Remmers, Michel; Aniculaesei, Adriana; Mar Castellanos Rodrigo, Maria del; Pichler, Alexander; Bindila, Daniela; Landrault, Emmanuelle; Weber, Jörg; Breynaert, Ludovic; Cakmak, Serkan; Weinstich, Karin; Lebely, Claire; Wollenweber, Frank; Brugirard, Sébastian; Cheripelli, Bharath; Pierskalla, Alexandra; Kalladka, Dheeraj; Moreton, Fiona; Dani, Krishna; Schill, Josef; Huang, Xuya; Evans, Nicholas; Touzé, Emmanuel; Wake, UP (Efficacy and Safety of Mri Based Thrombolysis inWake Up Stroke Trial) investigators administrative staff are as follows:; Patel, Bhavni; Cloud, Geoffrey; Touze, Emmanuel; Moynihan, Barry; Lovelock, Caroline; Choy, Lillian; Khan, Usman; Dixit, Anand; Tembl, Jose; Louw, Stephen; Broughton, David; Appleton, Jason; Acosta, Boris Raul; Leal, Joaquin Serena; Eendenburg, Van; Izaga, Mikel Terceno; Guillamon, Olga Belchí; Arenillas, Juan; Calleja, Ana; Cortijo, Elisa; Mulero, Patricia; Garrido, Alicia; Martinez, Alicia; Esperón, Carlos García; Guerrero, Cristina; Carrera, David; Lopez-Cancio, Elena; Palomeras, Ernest; Lucente, Giuseppe; Gomis, Meritxell; Isern, Irina; Becerra, Juan L.; Dorado, Laura; Grau, Laia; Ispierto, Lourdes; Almendrote, Miriam; Sivagnanaratham, Aravinth; Hernández, María; Jimenez, Marta; Rodríguez-Yáñez, Manuel; Navalpotro, Irene; Luna, Alain; Nederkoorn, Paul; Majoie, Charles; Fazekas, Franz; Fandler, Simon; Bayer-Karpinska, Anna; Gattringer, Thomas; Mutzenbach, Johannes; Höfner, Elmar; Kohlfürst, Heinz; Neumann-Haefelin, Tobias; Kellert, Lars; Opherk, Christian; Klein, Matthias; Harloff, Andreas; Bardutzky, Jürgen; Buggle, Florian; Kollmar, Rainer; Löbbe, Anna-Mareike; Moulin, Thierry; Bouamra, Benjamin; Bonnet, Louise; Bonnet, Anne-Laure; Haefelin, Tobias Neumann; Cogez, Julien; Li, Lin; Guettier, Sophie; Kar, Arindam; Geraghty, Olivia; Bojaryn, Urszula; Nallasivan, Arumugam; Gonzales, Miguel Blanco; Gorriz, David; Oberndorfer, Stefan; And, Elisabeth Prohaska; Prohaska, Elisabeth

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American Heart Association, Stroke, 1(51), p. 209-215, 2020

DOI: 10.1161/strokeaha.119.027390

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Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial

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Abstract

Background and Purpose— Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since stroke onset with higher intensities signifying longer time intervals. In the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke Trial), intravenous alteplase was effective in patients with unknown onset stroke selected by visual assessment of diffusion weighted imaging fluid-attenuated inversion recovery mismatch, that is, in those with no marked fluid-attenuated inversion recovery hyperintensity in the region of the acute diffusion weighted imaging lesion. In this post hoc analysis, we investigated whether quantitatively measured FLAIR-rSI modifies treatment effect of intravenous alteplase. Methods— FLAIR-rSI of stroke lesions was measured relative to signal intensity in a mirrored region in the contralesional hemisphere. The relationship between FLAIR-rSI and treatment effect on functional outcome assessed by the modified Rankin Scale (mRS) after 90 days was analyzed by binary logistic regression using different end points, that is, favorable outcome defined as mRS score of 0 to 1, independent outcome defined as mRS score of 0 to 2, ordinal analysis of mRS scores (shift analysis). All models were adjusted for National Institutes of Health Stroke Scale at symptom onset and stroke lesion volume. Results— FLAIR-rSI was successfully quantified in stroke lesions in 433 patients (86% of 503 patients included in WAKE-UP). Mean FLAIR-rSI was 1.06 (SD, 0.09). Interaction of FLAIR-rSI and treatment effect was not significant for mRS score of 0 to 1 ( P =0.169) and shift analysis ( P =0.086) but reached significance for mRS score of 0 to 2 ( P =0.004). We observed a smooth continuing trend of decreasing treatment effects in relation to clinical end points with increasing FLAIR-rSI. Conclusions— In patients in whom no marked parenchymal fluid-attenuated inversion recovery hyperintensity was detected by visual judgement in the WAKE-UP trial, higher FLAIR-rSI of diffusion weighted imaging lesions was associated with decreased treatment effects of intravenous thrombolysis. This parallels the known association of treatment effect and elapsing time of stroke onset.

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Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial

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