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American Association for the Advancement of Science, Science, 6336(356), 2017

DOI: 10.1126/science.aal1641

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Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

Journal article published in 2017 by Weichen Zhou, Michael J. McConnell, Lei Shi, John V. Moran, Mario Skarica, Jia Wang, Meiyan Wang, Yifan Wang, Margaret Wierman, Matthew Wolpert, Nenad Sestan, Mollie Woodworth, Xuefang Zhao, Maxwell A. Sherman, Alexej Abyzov and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Single-cell diversity in the brain The cells that make up an organism may all start from one genome, but somatic mutations mean that somewhere along the line of development, an organism's individual cellular genomes diverge. McConnell et al. review the implications and causes of single-cell genomic diversity for brain function. Somatic mutations caused by mobile genetic elements or errors in DNA repair may underlie certain neuropsychiatric disorders. Science , this issue p. eaal1641