Objective: To investigate the influence of social, economic and housing variables due to Tuberculosis/HIV in the state of Alagoas, Brazil. Methods: This is an ecological and cross-sectional study that evaluates the independent effect of variables from the Brazilian Institute of Geography and Statistics and United Nations Development Programme in the Annual Average Incidence Rate of Tuberculosis/HIV coinfection in the state of Alagoas from 2001 to 2016. We used Generalized Estimating Equation models implemented in SPSS software. Results: Among indicators related to cases of tuberculosis in people living with HIV in the municipalities of Alagoas, such as, the variables of household income per capita and percentage of households without piped water. A significant association in tests and measuring the quantification of important effects in the relationship among the strength association of each risk factors and the development of co-infection. Conclusion: The results can be consistent, allowing the identification of factors associated with the socioeconomic and socio-housing determination of TB/HIV co-infection in the state of Alagoas.