Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment
Journal article published in 2021 by
Olivia Goode 
,
Ashley Smith,
Ashraf Zarkan ,
Jehangir Cama,
Brandon M. Invergo ,
Daaniyah Belgami,
Santiago Caño-Muñiz,
Jeremy Metz,
Paul O’Neill,
Aaron Jeffries,
Isobel H. Norville,
Jonathan David,
David Summers,
Stefano Pagliara
,
Ashley Smith,
Ashraf Zarkan ,
Jehangir Cama,
Brandon M. Invergo ,
Daaniyah Belgami,
Santiago Caño-Muñiz,
Jeremy Metz,
Paul O’Neill,
Aaron Jeffries,
Isobel H. Norville,
Jonathan David,
David Summers,
Stefano Pagliara
This paper is made freely available by the publisher.
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Abstract
Persister and VBNC cells can phenotypically survive environmental stressors, such as antibiotic treatment, limitation of nutrients, and acid stress, and have been linked to chronic infections and antimicrobial resistance. It has recently been suggested that pH regulation might play a role in an organism’s phenotypic survival to antibiotics; however, this hypothesis remains to be tested.