Published in
American Association for the Advancement of Science, Science Translational Medicine, 617(13), 2021
DOI: 10.1126/scitranslmed.abe6201
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Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers
Journal article published in 2021 by
Daniel J. McGrail 
,
Patrick G. Pilié,
Hui Dai ,
Truong Nguyen Anh Lam ,
Yulong Liang,
Leonie Voorwerk,
Marleen Kok,
Xiang H.-F. Zhang ,
Jeffrey M. Rosen ,
Amy B. Heimberger ,
Christine B. Peterson ,
Eric Jonasch ,
Shiaw-Yih Lin
,
Patrick G. Pilié,
Hui Dai ,
Truong Nguyen Anh Lam ,
Yulong Liang,
Leonie Voorwerk,
Marleen Kok,
Xiang H.-F. Zhang ,
Jeffrey M. Rosen ,
Amy B. Heimberger ,
Christine B. Peterson ,
Eric Jonasch ,
Shiaw-Yih Lin
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Abstract
Endogenous and induced replication stress response defects promote tumor immunogenicity via generation of cytosolic single-stranded DNA.