Abstract Hyperactive comets have high water production rates, with inferred sublimation areas of order the surface area of the nucleus. Comets 46P/Wirtanen and 103P/Hartley 2 are two examples of this cometary class. Based on observations of comet Hartley 2 by the Deep Impact spacecraft, hyperactivity appears to be caused by the ejection of water-ice grains and/or water-ice-rich chunks of nucleus into the coma. These materials increase the sublimating surface area and yield high water production rates. The historic close approach of comet Wirtanen to Earth in 2018 afforded an opportunity to test Hartley 2–style hyperactivity in a second Jupiter-family comet. We present high spatial resolution, near-infrared spectroscopy of the inner coma of Wirtanen. No evidence for the 1.5 or 2.0 μm water-ice absorption bands is found in six 0.8–2.5 μm spectra taken around perihelion and closest approach to Earth. In addition, the strong 3.0 μm water-ice absorption band is absent in a 2.0–5.3 μm spectrum taken near perihelion. Using spectroscopic and sublimation lifetime models, we set constraints on the physical properties of the ice grains in the coma, assuming they are responsible for the comet’s hyperactivity. We rule out pure water-ice grains of any size, given their long lifetime. Instead, the hyperactivity of the nucleus and lack of water-ice absorption features in our spectra can be explained either by icy grains on the order of 1 μm in size with a small amount of low-albedo dust (greater than 0.5% by volume) or by large chunks containing significant amounts of water ice.