To design a residential or commercial building with high energy performance that would be economical at the same time, an analysis was performed that relates these two aspects of the problem. The first aspect is focused on evaluation of the thermal performance of a multi-layered wall in order to achieve the lowest energy consumption for heating and cooling. The second aspect of the analysis covered the choice of materials (type, thickness and price) so that the building has the lowest possible construction costs, but the best achieved thermal comfort. The three types of external walls with the same structure were analyzed in this paper. The lowest and highest values of the layer thickness offered by the manufacturer were chosen and their dynamic characteristics for the heat transfer were calculated. The following step was to perform optimization of the objective function, which was defined by the unit price of the material per mass of the material, that is, the economical aspect was provided. The genetic algorithm method was used to obtain the optimal thickness of the external wall layers that provided the best dynamic characteristics for the heat transfer in the defined conditions.