The study aimed to examine the effects of the quality of life on the adaptation of people with an intestinal stoma. Cross-sectional study with 152 people with an ostomy. Three instruments were used: the sociodemographic and clinical characterization, Scale for the Level of Adaptation of Ostomy Patients, and City of Hope Quality of Life - Ostomy Questionnaire. The multiple linear regression model, multivariate technique, and cluster were used. The determination coefficient showed that 94.1% of the variability of the Adaptation scores is explained by the dimensions of quality of life. It can be seen that the highest standardized coefficients are the psychological dimension (β = .386) and the social dimension (β = .365), in which they produce the greatest changes in the average adaptation scores. The psychological and social well-being dimensions are the ones that most contribute to raising the levels of adaptation.