Thieme Gruppe, Synthesis: Journal of Synthetic Organic Chemistry, 20(53), p. 3799-3814, 2021
DOI: 10.1055/a-1523-1409
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AbstractAminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. To increase the chemical diversity in this series, the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold was explored. About thirty newly functionalized thiophene-containing bicycles were obtained using various chemical reactions, paving the way for novel possibilities in medicinal chemistry projects.