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Royal Society of Chemistry, Chemical Science, 45(12), p. 15090-15103, 2021

DOI: 10.1039/d1sc04183e

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Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein–nanomaterial hybrids

Journal article published in 2021 by J. Groen ORCID, A. Palanca ORCID, A. Aires ORCID, J. J. Conesa, D. Maestro, S. Rehbein, M. Harkiolaki, A. V. Villar ORCID, A. L. Cortajarena ORCID, E. Pereiro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A novel 3D cryo correlative approach locates designed therapeutic protein–nanomaterial hybrids in whole cells with high specificity and resolution. Detection of treatment-induced morphological changes, crucial for pre-clinical studies, are revealed.