Published in
Royal Society of Chemistry, Chemical Science, 45(12), p. 15090-15103, 2021
DOI: 10.1039/d1sc04183e
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Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein–nanomaterial hybrids
Journal article published in 2021 by
J. Groen 
,
A. Palanca ,
A. Aires ,
J. J. Conesa,
D. Maestro,
S. Rehbein,
M. Harkiolaki,
A. V. Villar ,
A. L. Cortajarena ,
E. Pereiro
,
A. Palanca ,
A. Aires ,
J. J. Conesa,
D. Maestro,
S. Rehbein,
M. Harkiolaki,
A. V. Villar ,
A. L. Cortajarena ,
E. Pereiro
This paper is made freely available by the publisher.
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Abstract
A novel 3D cryo correlative approach locates designed therapeutic protein–nanomaterial hybrids in whole cells with high specificity and resolution. Detection of treatment-induced morphological changes, crucial for pre-clinical studies, are revealed.