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American Association for the Advancement of Science, Science, 6658(381), 2023

DOI: 10.1126/science.abq5693

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DNA Methylation Networks Underlying Mammalian Traits

Journal article published in 2021 by Amin Haghani ORCID, Joshua Zhang ORCID, Caesar Z. Li ORCID, Ake T. Lu ORCID, Julia Ablaeva ORCID, Victoria A. Acosta-Rodríguez ORCID, Todd R. Robeck ORCID, Danielle M. Adams ORCID, Abdulaziz N. Alagaili ORCID, Javier Almunia ORCID, Ajoy Aloysius ORCID, Nabil M. S. Amor ORCID, Reza Ardehali ORCID, Adriana Arneson ORCID, C. Scott Baker ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Data provided by SHERPA/RoMEO

Abstract

Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species.