Objective: To map the available evidence about the prescription of antimicrobials in Primary Health Care. Methods: A Scoping Review has been proposed based on the procedures recommended by the Joanna Briggs Institute. Results: This review included a total of 16 studies. The articles compiled demonstrated that this theme is the center of discussion, in a linear manner, over the past 12 years. Among the studies, 37.5% occurred in Brazil, and regarding the prescription of antimicrobials analyzed in studies, amoxicillin was the most prescribed, the physician was the prescribing professional in 12 studies, and the prescriptions were mostly intended for the general population (children, adolescents, adults and the elderly). Conclusion: This review ratifies the premise of rational use of antimicrobials promoted by the World Health Organization through the goals of sustainable development when understanding that these drugs have been considerably prescribed in the daily routine of Primary Health Care and there is no specific system to control and monitor their rational use.