SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

Dejnirattisai, Wanwisa; Huo, Jiandong; Zhou, Daming; Avinoam, Ori; Bahar, Mohammad; Zahradník, Jiří; Skelly, Donal; Adele, Sandra; Johnson, Sile Ann; Amini, Ali; Ritter, Thomas G.; Mason, Chris; Supasa, Piyada; Dold, Christina; Duyvesteyn, Helen M. E.; Pan, Daniel; Assadi, Sara; Bellass, Adam; Ginn, Helen M.; Omo-Dare, Nicola; Liu, Chang; Baillie, Vicky; Koeckerling, David; Flaxman, Amy; Jenkin, Daniel; Mentzer, Alexander J.; Aley, Parvinder K.; Voysey, Merryn; Costa Clemens, Sue Ann; Naveca, Felipe Gomes; Nascimento, Valdinete; Nascimento, Fernanda; Fernandes da Costa, Cristiano; Resende, Paola Cristina; Pauvolid-Correa, Alex; Siqueira, Marilda M.; Tuekprakhon, Aekkachai; Khan, Suman; Serafin, Natali; Kwatra, Gaurav; Da Silva, Kelly; Madhi, Shabir A.; Nutalai, Rungtiwa; Nunes, Marta C.; Malik, Tariq; Openshaw, Peter J. M.; Baillie, J. Kenneth; Wang, Beibei; Semple, Malcolm G.; Townsend, Alain R.; Huang, Kuan-Ying A.; Tan, Tiong Kit; Dijokaite, Aiste; Carroll, Miles W.; Klenerman, Paul; Barnes, Eleanor; Dunachie, Susanna J.; Constantinides, Bede; Webster, Hermione; Crook, Derrick; Pollard, Andrew J.; Lambe, Teresa; Paterson, Neil G.; Williams, Mark A.; Hall, David R.; Fry, Elizabeth E.; Mongkolsapaya, Juthathip; Ren, Jingshan; Schreiber, Gideon; Stuart, David I.; Conlon, Christopher; Deeks, Alexandra S.; Frater, John; Frending, Lisa; Gardiner, Siobhan; Jämsén, Anni; Jeffery, Katie; Malone, Tom; Phillips, Eloise; Rothwell, Lucy; da Silva Filipe, Ana; Stafford, Lizzie; de Silva, Thushan; Openshaw, Peter J.-M.; dos Santos Correia, Gonçalo; Carson, Gail; Alex, Beatrice; Andrikopoulos, Petros; Bach, Benjamin; Barclay, Wendy S.; Bogaert, Debby; Chand, Meera; Chechi, Kanta; Cooke, Graham S.; Screaton, Gavin R.; Docherty, Annemarie B.; Dumas, Marc-Emmanuel; Dunning, Jake; Fletcher, Tom; Green, Christoper A.; Greenhalf, William; Griffin, Julian L.; Gupta, Rishi K.; Harrison, Ewen M.; Hiscox, Julian A.; Wai Ho, Antonia Ying; Horby, Peter W.; Ijaz, Samreen; Khoo, Saye; Law, Andrew; Lewis, Matthew R.; Liggi, Sonia; Lim, Wei Shen; Maslen, Lynn; Merson, Laura; Meynert, Alison M.; Moore, Shona C.; Noursadeghi, Mahdad; Olanipekun, Michael; Osagie, Anthonia; Palmarini, Massimo; Palmieri, Carlo; Paxton, William A.; Pollakis, Georgios; Price, Nicholas; Rambaut, Andrew; Robertson, David L.; Russell, Clark D.; Sancho-Shimizu, Vanessa; Sands, Caroline J.; Scott, Janet T.; Sigfrid, Louise; Solomon, Tom; Sriskandan, Shiranee; Stuart, David; Summers, Charlotte; Swann, Olivia V.; Takats, Zoltan; Takis, Panteleimon; Tedder, Richard S.; Thompson, Aa Roger; Thomson, Emma C.; Thwaites, Ryan S.; Turtle, Lance C.-W.; Zambon, Maria; Hardwick, Hayley; Donohue, Chloe; Griffiths, Fiona; Oosthuyzen, Wilna; Donegan, Cara; Spencer, Rebecca G.; Norman, Lisa; Pius, Riinu; Drake, Thomas M.; Fairfield, Cameron J.; Knight, Stephen R.; Mclean, Kenneth A.; Murphy, Derek; Shaw, Catherine A.; Dalton, Jo; Girvan, Michelle; Saviciute, Egle; Roberts, Stephanie; Harrison, Janet; Marsh, Laura; Connor, Marie; Halpin, Sophie; Jackson, Clare; Gamble, Carrol; Plotkin, Daniel; Lee, James; Leeming, Gary; Wham, Murray; Clohisey, Sara; Hendry, Ross; Scott-Brown, James; Shaw, Victoria; McDonald, Sarah E.; Keating, Seán; Ahmed, Katie A.; Armstrong, Jane A.; Ashworth, Milton; Asiimwe, Innocent G.; Bakshi, Siddharth; Barlow, Samantha L.; Booth, Laura; Brennan, Benjamin; Bullock, Katie; Catterall, Benjamin W.-A.; Clark, Jordan J.; Clarke, Emily A.; Cole, Sarah; Cooper, Louise; Cox, Helen; Davis, Christopher; Dincarslan, Oslem; Dunn, Chris; Dyer, Philip; Elliott, Angela; Evans, Anthony; Finch, Lorna; Fisher, Lewis W.-S.; Foster, Terry; Garcia-Dorival, Isabel; Gunning, Philip; Hartley, Catherine; Jensen, Rebecca L.; Jones, Christopher B.; Jones, Trevor R.; Khandaker, Shadia; King, Katharine; Kiy, Robyn T.; Koukorava, Chrysa; Lake, Annette; van Tonder, Libby; Lant, Suzannah; Latawiec, Diane; Lavelle-Langham, Lara; Lefteri, Daniella; Lett, Lauren; Livoti, Lucia A.; Mancini, Maria; McDonald, Sarah; McEvoy, Laurence; Hme, Duyvesteyn; McLauchlan, John; Metelmann, Soeren; Miah, Nahida S.; Middleton, Joanna; Mitchell, Joyce; Murphy, Ellen G.; Penrice-Randal, Rebekah; Pilgrim, Jack; Prince, Tessa; Reynolds, Will; Ridley, P. Matthew; Sales, Debby; Shaw, Victoria E.; Shears, Rebecca K.; Small, Benjamin; Subramaniam, Krishanthi S.; Szemiel, Agnieska; Taggart, Aislynn; Tanianis-Hughes, Jolanta; Thomas, Jordan; Trochu, Erwan; Wilcock, Eve; Zhang, J. Eunice; Flaherty, Lisa; Maziere, Nicole; Cass, Emily; Carracedo, Alejandra Doce; Carlucci, Nicola; Holmes, Anthony; Massey, Hannah; Murphy, Lee; McCafferty, Sarah; Clark, Richard; Hm, Ginn; Fawkes, Angie; Morrice, Kirstie; Maclean, Alan; Wrobel, Nicola; Donnelly, Lorna; Coutts, Audrey; Hafezi, Katarzyna; MacGillivray, Louise; Gilchrist, Tammy; Adeniji, Kayode; Agranoff, Daniel; Agwuh, Ken; Ail, Dhiraj; Aldera, Erin L.; Alegria, Ana; Allen, Sam; Angus, Brian; Ashish, Abdul; Atkinson, Dougal; Bari, Shahedal; Barlow, Gavin; Barnass, Stella; Barrett, Nicholas; Bassford, Christopher; Basude, Sneha; Baxter, David; Beadsworth, Michael; Bernatoniene, Jolanta; Berridge, John; Berry, Colin; Best, Nicola; Bothma, Pieter; Chadwick, David; Brittain-Long, Robin; Aj, Mentzer; Bulteel, Naomi; Burden, Tom; Burtenshaw, Andrew; Caruth, Vikki; Chambler, Duncan; Chee, Nigel; Child, Jenny; Chukkambotla, Srikanth; Clark, Tom; Collini, Paul; Cosgrove, Catherine; Cupitt, Jason; Cutino-Moguel, Maria-Teresa; Dark, Paul; Dawson, Chris; Dervisevic, Samir; Donnison, Phil; Douthwaite, Sam; Drummond, Andrew; DuRand, Ingrid; Dushianthan, Ahilanadan; Dyer, Tristan; Evans, Cariad; Eziefula, Chi; Fegan, Chrisopher; Finn, Adam; Fullerton, Duncan; Garg, Sanjeev; Garg, Atul; Gkrania-Klotsas, Effrossyni; Godden, Jo; Goldsmith, Arthur; Graham, Clive; Hardy, Elaine; Hartshorn, Stuart; Harvey, Daniel; Havalda, Peter; Hawcutt, Daniel B.; Hobrok, Maria; Hodgson, Luke; Hormis, Anil; Jacobs, Michael; Jain, Susan; Jennings, Paul; Kaliappan, Agilan; Kasipandian, Vidya; Kegg, Stephen; Kelsey, Michael; Kendall, Jason; Kerrison, Caroline; Kerslake, Ian; Koch, Oliver; Koduri, Gouri; Koshy, George; Laha, Shondipon; Laird, Steven; Larkin, Susan; Leiner, Tamas; Lillie, Patrick; Limb, James; Linnett, Vanessa; Little, Jeff; Lyttle, Mark; MacMahon, Michael; MacNaughton, Emily; Mankregod, Ravish; Masson, Huw; Matovu, Elijah; McCullough, Katherine; McEwen, Ruth; Meda, Manjula; Mills, Gary; Minton, Jane; Mirfenderesky, Mariyam; Mohandas, Kavya; Mok, Quen; Moon, James; Moore, Elinoor; Morgan, Patrick; Morris, Craig; Mortimore, Katherine; Moses, Samuel; Mpenge, Mbiye; Mulla, Rohinton; Murphy, Michael; Nagel, Megan; Nagarajan, Thapas; Nelson, Mark; Norris, Lillian; O’Shea, Matthew K.; Otahal, Igor; Ostermann, Marlies; Pais, Mark; Panchatsharam, Selva; Papakonstantinou, Danai; Paraiso, Hassan; Patel, Brij; Pattison, Natalie; Pepperell, Justin; Peters, Mark; Phull, Mandeep; Pintus, Stefania; Pooni, Jagtur Singh; Planche, Tim; Post, Frank; Price, David; Prout, Rachel; Rae, Nikolas; Reschreiter, Henrik; Reynolds, Tim; Richardson, Neil; Roberts, Mark; Roberts, Devender; Rose, Alistair; Rousseau, Guy; Ruge, Bobby; Ryan, Brendan; Saluja, Taranprit; Schmid, Matthias L.; Shah, Aarti; Shanmuga, Prad; Sharma, Anil; Shawcross, Anna; Sizer, Jeremy; Shankar-Hari, Manu; Smith, Richard; Snelson, Catherine; Spittle, Nick; Staines, Nikki; Stambach, Tom; Stewart, Richard; Subudhi, Pradeep; Szakmany, Tamas; Tatham, Kate; Thomas, Jo; Thompson, Chris; Thompson, Robert; Tridente, Ascanio; Tupper-Carey, Darell; Twagira, Mary; Vallotton, Nick; Vancheeswaran, Rama; Vincent-Smith, Lisa; Visuvanathan, Shico; Vuylsteke, Alan; Waddy, Sam; Wake, Rachel; Walden, Andrew; Welters, Ingeborg; Whitehouse, Tony; Whittaker, Paul; Whittington, Ashley; Papineni, Padmasayee; Wijesinghe, Meme; Williams, Martin; Wilson, Lawrence; Winchester, Stephen; Wiselka, Martin; Wolverson, Adam; Wootton, Daniel G.; Workman, Andrew; Yates, Bryan; Gr, Screaton; Young, Peter

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Donal Skelly
Dejnirattisai et al., 2022

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Cell Press, Cell, 2022

DOI: 10.1016/j.cell.2021.12.046

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@article{Dejnirattisai2022,
  author = {Dejnirattisai, Wanwisa and Huo, Jiandong and Zhou, Daming and Avinoam, Ori and Bahar, Mohammad and Zahradník, Jiří and Skelly, Donal and Adele, Sandra and Johnson, Sile Ann and Amini, Ali and Ritter, Thomas G. and Mason, Chris and Supasa, Piyada and Dold, Christina and Duyvesteyn, Helen M. E. and Pan, Daniel and Assadi, Sara and Bellass, Adam and Ginn, Helen M. and Omo-Dare, Nicola and Liu, Chang and Baillie, Vicky and Koeckerling, David and Flaxman, Amy and Jenkin, Daniel and Mentzer, Alexander J. and Aley, Parvinder K. and Voysey, Merryn and Costa Clemens, Sue Ann and Naveca, Felipe Gomes and Nascimento, Valdinete and Nascimento, Fernanda and Fernandes da Costa, Cristiano and Resende, Paola Cristina and Pauvolid-Correa, Alex and Siqueira, Marilda M. and Tuekprakhon, Aekkachai and Khan, Suman and Serafin, Natali and Kwatra, Gaurav and Da Silva, Kelly and Madhi, Shabir A. and Nutalai, Rungtiwa and Nunes, Marta C. and Malik, Tariq and Openshaw, Peter J. M. and Baillie, J. Kenneth and Wang, Beibei and Semple, Malcolm G. and Townsend, Alain R. and Huang, Kuan-Ying A. and Tan, Tiong Kit and Dijokaite, Aiste and Carroll, Miles W. and Klenerman, Paul and Barnes, Eleanor and Dunachie, Susanna J. and Constantinides, Bede and Webster, Hermione and Crook, Derrick and Pollard, Andrew J. and Lambe, Teresa and Paterson, Neil G. and Williams, Mark A. and Hall, David R. and Fry, Elizabeth E. and Mongkolsapaya, Juthathip and Ren, Jingshan and Schreiber, Gideon and Stuart, David I. and Conlon, Christopher and Deeks, Alexandra S. and Frater, John and Frending, Lisa and Gardiner, Siobhan and Jämsén, Anni and Jeffery, Katie and Malone, Tom and Phillips, Eloise and Rothwell, Lucy and da Silva Filipe, Ana and Stafford, Lizzie and de Silva, Thushan and Openshaw, Peter J.-M. and dos Santos Correia, Gonçalo and Carson, Gail and Alex, Beatrice and Andrikopoulos, Petros and Bach, Benjamin and Barclay, Wendy S. and Bogaert, Debby and Chand, Meera and Chechi, Kanta and Cooke, Graham S. and Screaton, Gavin R. and Docherty, Annemarie B. and Dumas, Marc-Emmanuel and Dunning, Jake and Fletcher, Tom and Green, Christoper A. and Greenhalf, William and Griffin, Julian L. and Gupta, Rishi K. and Harrison, Ewen M. and Hiscox, Julian A. and Wai Ho, Antonia Ying and Horby, Peter W. and Ijaz, Samreen and Khoo, Saye and Law, Andrew and Lewis, Matthew R. and Liggi, Sonia and Lim, Wei Shen and Maslen, Lynn and Merson, Laura and Meynert, Alison M. and Moore, Shona C. and Noursadeghi, Mahdad and Olanipekun, Michael and Osagie, Anthonia and Palmarini, Massimo and Palmieri, Carlo and Paxton, William A. and Pollakis, Georgios and Price, Nicholas and Rambaut, Andrew and Robertson, David L. and Russell, Clark D. and Sancho-Shimizu, Vanessa and Sands, Caroline J. and Scott, Janet T. and Sigfrid, Louise and Solomon, Tom and Sriskandan, Shiranee and Stuart, David and Summers, Charlotte and Swann, Olivia V. and Takats, Zoltan and Takis, Panteleimon and Tedder, Richard S. and Thompson, Aa Roger and Thomson, Emma C. and Thwaites, Ryan S. and Turtle, Lance C.-W. and Zambon, Maria and Hardwick, Hayley and Donohue, Chloe and Griffiths, Fiona and Oosthuyzen, Wilna and Donegan, Cara and Spencer, Rebecca G. and Norman, Lisa and Pius, Riinu and Drake, Thomas M. and Fairfield, Cameron J. and Knight, Stephen R. and Mclean, Kenneth A. and Murphy, Derek and Shaw, Catherine A. and Dalton, Jo and Girvan, Michelle and Saviciute, Egle and Roberts, Stephanie and Harrison, Janet and Marsh, Laura and Connor, Marie and Halpin, Sophie and Jackson, Clare and Gamble, Carrol and Plotkin, Daniel and Lee, James and Leeming, Gary and Wham, Murray and Clohisey, Sara and Hendry, Ross and Scott-Brown, James and Shaw, Victoria and McDonald, Sarah E. and Keating, Seán and Ahmed, Katie A. and Armstrong, Jane A. and Ashworth, Milton and Asiimwe, Innocent G. and Bakshi, Siddharth and Barlow, Samantha L. and Booth, Laura and Brennan, Benjamin and Bullock, Katie and Catterall, Benjamin W.-A. and Clark, Jordan J. and Clarke, Emily A. and Cole, Sarah and Cooper, Louise and Cox, Helen and Davis, Christopher and Dincarslan, Oslem and Dunn, Chris and Dyer, Philip and Elliott, Angela and Evans, Anthony and Finch, Lorna and Fisher, Lewis W.-S. and Foster, Terry and Garcia-Dorival, Isabel and Gunning, Philip and Hartley, Catherine and Jensen, Rebecca L. and Jones, Christopher B. and Jones, Trevor R. and Khandaker, Shadia and King, Katharine and Kiy, Robyn T. and Koukorava, Chrysa and Lake, Annette and van Tonder, Libby and Lant, Suzannah and Latawiec, Diane and Lavelle-Langham, Lara and Lefteri, Daniella and Lett, Lauren and Livoti, Lucia A. and Mancini, Maria and McDonald, Sarah and McEvoy, Laurence and Hme, Duyvesteyn and McLauchlan, John and Metelmann, Soeren and Miah, Nahida S. and Middleton, Joanna and Mitchell, Joyce and Murphy, Ellen G. and Penrice-Randal, Rebekah and Pilgrim, Jack and Prince, Tessa and Reynolds, Will and Ridley, P. Matthew and Sales, Debby and Shaw, Victoria E. and Shears, Rebecca K. and Small, Benjamin and Subramaniam, Krishanthi S. and Szemiel, Agnieska and Taggart, Aislynn and Tanianis-Hughes, Jolanta and Thomas, Jordan and Trochu, Erwan and Wilcock, Eve and Zhang, J. Eunice and Flaherty, Lisa and Maziere, Nicole and Cass, Emily and Carracedo, Alejandra Doce and Carlucci, Nicola and Holmes, Anthony and Massey, Hannah and Murphy, Lee and McCafferty, Sarah and Clark, Richard and Hm, Ginn and Fawkes, Angie and Morrice, Kirstie and Maclean, Alan and Wrobel, Nicola and Donnelly, Lorna and Coutts, Audrey and Hafezi, Katarzyna and MacGillivray, Louise and Gilchrist, Tammy and Adeniji, Kayode and Agranoff, Daniel and Agwuh, Ken and Ail, Dhiraj and Aldera, Erin L. and Alegria, Ana and Allen, Sam and Angus, Brian and Ashish, Abdul and Atkinson, Dougal and Bari, Shahedal and Barlow, Gavin and Barnass, Stella and Barrett, Nicholas and Bassford, Christopher and Basude, Sneha and Baxter, David and Beadsworth, Michael and Bernatoniene, Jolanta and Berridge, John and Berry, Colin and Best, Nicola and Bothma, Pieter and Chadwick, David and Brittain-Long, Robin and Aj, Mentzer and Bulteel, Naomi and Burden, Tom and Burtenshaw, Andrew and Caruth, Vikki and Chambler, Duncan and Chee, Nigel and Child, Jenny and Chukkambotla, Srikanth and Clark, Tom and Collini, Paul and Cosgrove, Catherine and Cupitt, Jason and Cutino-Moguel, Maria-Teresa and Dark, Paul and Dawson, Chris and Dervisevic, Samir and Donnison, Phil and Douthwaite, Sam and Drummond, Andrew and DuRand, Ingrid and Dushianthan, Ahilanadan and Dyer, Tristan and Evans, Cariad and Eziefula, Chi and Fegan, Chrisopher and Finn, Adam and Fullerton, Duncan and Garg, Sanjeev and Garg, Atul and Gkrania-Klotsas, Effrossyni and Godden, Jo and Goldsmith, Arthur and Graham, Clive and Hardy, Elaine and Hartshorn, Stuart and Harvey, Daniel and Havalda, Peter and Hawcutt, Daniel B. and Hobrok, Maria and Hodgson, Luke and Hormis, Anil and Jacobs, Michael and Jain, Susan and Jennings, Paul and Kaliappan, Agilan and Kasipandian, Vidya and Kegg, Stephen and Kelsey, Michael and Kendall, Jason and Kerrison, Caroline and Kerslake, Ian and Koch, Oliver and Koduri, Gouri and Koshy, George and Laha, Shondipon and Laird, Steven and Larkin, Susan and Leiner, Tamas and Lillie, Patrick and Limb, James and Linnett, Vanessa and Little, Jeff and Lyttle, Mark and MacMahon, Michael and MacNaughton, Emily and Mankregod, Ravish and Masson, Huw and Matovu, Elijah and McCullough, Katherine and McEwen, Ruth and Meda, Manjula and Mills, Gary and Minton, Jane and Mirfenderesky, Mariyam and Mohandas, Kavya and Mok, Quen and Moon, James and Moore, Elinoor and Morgan, Patrick and Morris, Craig and Mortimore, Katherine and Moses, Samuel and Mpenge, Mbiye and Mulla, Rohinton and Murphy, Michael and Nagel, Megan and Nagarajan, Thapas and Nelson, Mark and Norris, Lillian and O’Shea, Matthew K. and Otahal, Igor and Ostermann, Marlies and Pais, Mark and Panchatsharam, Selva and Papakonstantinou, Danai and Paraiso, Hassan and Patel, Brij and Pattison, Natalie and Pepperell, Justin and Peters, Mark and Phull, Mandeep and Pintus, Stefania and Pooni, Jagtur Singh and Planche, Tim and Post, Frank and Price, David and Prout, Rachel and Rae, Nikolas and Reschreiter, Henrik and Reynolds, Tim and Richardson, Neil and Roberts, Mark and Roberts, Devender and Rose, Alistair and Rousseau, Guy and Ruge, Bobby and Ryan, Brendan and Saluja, Taranprit and Schmid, Matthias L. and Shah, Aarti and Shanmuga, Prad and Sharma, Anil and Shawcross, Anna and Sizer, Jeremy and Shankar-Hari, Manu and Smith, Richard and Snelson, Catherine and Spittle, Nick and Staines, Nikki and Stambach, Tom and Stewart, Richard and Subudhi, Pradeep and Szakmany, Tamas and Tatham, Kate and Thomas, Jo and Thompson, Chris and Thompson, Robert and Tridente, Ascanio and Tupper-Carey, Darell and Twagira, Mary and Vallotton, Nick and Vancheeswaran, Rama and Vincent-Smith, Lisa and Visuvanathan, Shico and Vuylsteke, Alan and Waddy, Sam and Wake, Rachel and Walden, Andrew and Welters, Ingeborg and Whitehouse, Tony and Whittaker, Paul and Whittington, Ashley and Papineni, Padmasayee and Wijesinghe, Meme and Williams, Martin and Wilson, Lawrence and Winchester, Stephen and Wiselka, Martin and Wolverson, Adam and Wootton, Daniel G. and Workman, Andrew and Yates, Bryan and Gr, Screaton and Young, Peter},
  doi = {10.1016/j.cell.2021.12.046},
  journal = {Cell},
  month = {jan},
  title = {SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses},
  url = {https://oadoi.org/10.1016/j.cell.2021.12.046},
  year = {2022}
}

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