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American Association for the Advancement of Science, Science Advances, 38(7), 2021

DOI: 10.1126/sciadv.abf4468

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Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

Journal article published in 2021 by Ana Tapia-Abellán ORCID, Diego Angosto-Bazarra ORCID, Cristina Alarcón-Vila, María C. Baños ORCID, Iva Hafner-Bratkovič ORCID, Baldomero Oliva ORCID, Pablo Pelegrín ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The specific NLRP3 N-terminal domain is essential for NLRP3 activation and inflammasome formation in response to K + efflux.