Published in
Elsevier, The Lancet Respiratory Medicine, 4(10), p. 367-377, 2022
DOI: 10.1016/s2213-2600(21)00461-6
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Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis
Journal article published in 2022 by
Manoj V. Maddali,
Matthew Churpek,
Tai Pham,
Emanuele Rezoagli,
Hanjing Zhuo,
Wendi Zhao,
June He,
Kevin L. Delucchi,
Chunxue Wang,
Nancy Wickersham,
J. Brennan McNeil,
Alejandra Jauregui,
Serena Ke,
Kathryn Vessel,
Antonio Gomez
and other authors.
Manoj V. Maddali,
Matthew Churpek,
Tai Pham,
Emanuele Rezoagli,
Hanjing Zhuo,
Wendi Zhao,
June He,
Kevin L. Delucchi,
Chunxue Wang,
Nancy Wickersham,
J. Brennan McNeil,
Alejandra Jauregui,
Serena Ke,
Kathryn Vessel,
Antonio Gomez,
Carolyn M. Hendrickson,
Kirsten N. Kangelaris,
Aartik Sarma,
Aleksandra Leligdowicz,
Kathleen D. Liu,
Michael A. Matthay,
Lorraine B. Ware 
,
John G. Laffey,
Giacomo Bellani,
Carolyn S. Calfee,
Pratik Sinha,
Fernando Rios,
Frank Van Haren,
T. Sottiaux,
Fredy S. Lora,
Luciano C. Azevedo,
P. Depuydt,
Eddy Fan,
Guillermo Bugedo,
Haibo Qiu,
Marcos Gonzalez,
Juan Silesky,
Vladimir Cerny,
Jonas Nielsen,
Manuel Jibaja,
Tài Pham,
Hermann Wrigge,
Dimitrios Matamis,
Jorge Luis Ranero,
S. M. Hashemian,
Pravin Amin,
Kevin Clarkson,
Kiyoyasu Kurahashi,
Asisclo Villagomez,
Amine Ali Zeggwagh,
Leo M. Heunks,
Jon Henrik Laake,
Jose Emmanuel Palo,
Antero do Vale Fernandes,
Dorel Sandesc,
Yaasen Arabi,
Vesna Bumbasierevic,
Nicolas Nin,
Jose A. Lorente,
Anders Larsson,
Lise Piquilloud,
Fekri Abroug,
Daniel F. McAuley,
Lia McNamee,
Javier Hurtado,
Ed Bajwa,
Gabriel Démpaire,
Guy M. Francois,
Hektor Sula,
Lordian Nunci,
Alma Cani,
Alan Zazu,
Christian Dellera,
Carolina S. Insaurralde,
Risso V. Alejandro,
Julio Daldin,
Mauricio Vinzio,
Ruben O. Fernandez,
Luis P. Cardonnet,
Lisandro R. Bettini,
Mariano Carboni Bisso,
Emilio M. Osman,
Mariano G. Setten,
Pablo Lovazzano,
Javier Alvarez,
Veronica Villar,
Cesar Milstein,
Norberto C. Pozo,
Nicolas Grubissich,
Gustavo A. Plotnikow,
Daniela N. Vasquez,
Santiago Ilutovich,
Norberto Tiribelli,
Ariel Chena,
Carlos A. Pellegrini,
María G. Saenz,
Elisa Estenssoro,
Matias Brizuela,
Hernan Gianinetto,
Pablo E. Gomez,
Valeria I. Cerrato,
Marco G. Bezzi,
Silvina A. Borello,
Flavia A. Loiacono,
Adriana M. Fernandez,
Serena Knowles ,
Claire Reynolds,
Deborah M. Inskip,
Jennene J. Miller,
Jing Kong,
Christina Whitehead,
Shailesh Bihari,
Aylin Seven,
Amanda Krstevski,
Helen J. Rodgers,
Rebecca T. Millar,
Toni E. Mckenna,
Irene M. Bailey,
Gabrielle C. Hanlon,
Anders Aneman,
Joan M. Lynch,
Raman Azad,
John Neal,
Paul W. Woods,
Brigit L. Roberts,
Mark R. Kol,
Helen S. Wong,
Katharina C. Riss,
Thomas Staudinger,
Xavier Wittebole,
Caroline Berghe,
Pierre A. Bulpa,
Alain M. Dive,
Rik Verstraete,
Herve Lebbinck,
Pieter Depuydt,
Joris Vermassen,
Philippe Meersseman,
Helga Ceunen,
Jonas I. Rosa,
Daniel O. Beraldo,
Claudio Piras,
Adenilton M. R. Ampinelli,
Antonio P. Nassar Jr,
Sergio Mataloun,
Marcelo Moock,
Marlus M. Thompson,
Claudio H. Gonçalves,
Ana Carolina P. Antônio,
Aline Ascoli,
Rodrigo S. Biondi,
Danielle C. Fontenele,
Danielle Nobrega,
Vanessa M. Sales,
Suresh Shindhe,
Dk Maizatul Aiman B. Pg Hj Ismail,
John Laffey,
Francois Beloncle,
Kyle G. Davies,
Rob Cirone,
Venika Manoharan,
Mehvish Ismail,
Ewan C. Goligher,
Mandeep Jassal,
Erin Nishikawa,
Areej Javeed,
Gerard Curley,
Nuttapol Rittayamai,
Matteo Parotto,
Niall D. Ferguson,
Sangeeta Mehta,
Jenny Knoll,
Antoine Pronovost,
Sergio Canestrini,
Alejandro R. Bruhn,
Patricio H. Garcia,
Felipe A. Aliaga,
Pamela A. Farías,
Jacob S. Yumha,
Claudia A. Ortiz,
Javier E. Salas,
Alejandro A. Saez,
Luis D. Vega,
Eduardo F. Labarca,
Felipe T. Martinez,
Nicolás G. Carreño,
Pilar Lora,
Haitao Liu,
Ling Liu,
Rui Tang,
Xiaoming Luo,
Youzhong An,
Huiying Zhao,
Yan Gao,
Zhe Zhai,
Zheng L. Ye,
Wei Wang,
Wenwen Li,
Qingdong Li,
Ruiqiang Zheng,
Wenkui Yu,
Juanhong Shen,
Xinyu Li,
Tao Yu,
Weihua Lu,
Ya Q. Wu,
Xiao B. Huang,
Zhenyang He,
Yuanhua Lu,
Hui Han,
Fan Zhang,
Renhua Sun,
Hua X. Wang,
Shu H. Qin,
Bao H. Zhu,
Jun Zhao,
Jian Liu,
Bin Li,
Jing L. Liu,
Fa C. Zhou,
Qiong J. Li,
Xing Y. Zhang,
Zhou Li-Xin,
Qiang Xin-Hua,
Liangyan Jiang,
Yuan N. Gao,
Xian Y. Zhao,
Yuan Y. Li,
Xiao L. Li,
Chunting Wang,
Qingchun Yao,
Rongguo Yu,
Kai Chen,
Huanzhang Shao,
Bingyu Qin,
Qing Q. Huang,
Wei H. Zhu,
Ai Y. Hang,
Ma X. Hua,
Yimin Li,
Yonghao Xu,
Yu D. Di,
Long L. Ling,
Tie H. Qin,
Shou H. Wang,
Junping Qin,
Yi Han,
Suming Zhou,
Monica P. Vargas,
Juan I. Silesky Jimenez,
Manuel A. González Rojas,
Jaime E. Solis-Quesada,
Christian M. Ramirez-Alfaro,
Jan Máca,
Peter Sklienka,
Jakob Gjedsted,
Aage Christiansen,
Boris G. Villamagua,
Miguel Llano,
Philippe Burtin,
Gautier Buzancais,
Pascal Beuret,
Nicolas Pelletier,
Satar Mortaza,
Alain Mercat,
Jonathan Chelly,
Sébastien Jochmans,
Nicolas Terzi,
Cédric Daubin,
Guillaume Carteaux,
Nicolas de Prost,
Jean-Daniel Chiche,
Fabrice Daviaud,
Muriel Fartoukh,
Guillaume Barberet,
Jerome Biehler,
Jean Dellamonica,
Denis Doyen,
Jean-Michel Arnal,
Anais Briquet,
Sami Hraiech,
Laurent Papazian,
Arnaud Follin,
Damien Roux,
Jonathan Messika,
Evangelos Kalaitzis,
Laurence Dangers,
Alain Combes,
Siu-Ming Au,
Gaetan Béduneau,
Dorothée Carpentier,
Elie H. Zogheib,
Herve Dupont,
Sylvie Ricome,
Francesco L. Santoli,
Sebastien L. Besset,
Philippe Michel,
Bruno Gelée,
Pierre-Eric Danin,
Bernard Goubaux,
Philippe J. Crova,
Nga T. Phan,
Frantz Berkelmans,
Julio C. Badie,
Romain Tapponnier,
Josette Gally,
Samy Khebbeb,
Jean-Etienne Herbrecht,
Francis Schneider,
Pierre-Louis M. Declercq,
Jean-Philippe Rigaud,
Jacques Duranteau,
Anatole Harrois,
Russell Chabanne,
Julien Marin,
Charlene Bigot,
Sandrine Thibault,
Mohammed Ghazi,
Messabi Boukhazna,
Salem Ould Zein,
Jack R. Richecoeur,
Daniele M. Combaux,
Fabien Grelon,
Charlene Le Moal,
Elise P. Sauvadet,
Adrien Robine,
Virginie Lemiale,
Danielle Reuter,
Martin Dres,
Alexandre Demoule,
Dany Goldgran-Toledano,
Loredana Baboi,
Claude Guérin,
Ralph Lohner,
Jens Kraßler,
Susanne Schäfer,
Kai D. Zacharowski,
Patrick Meybohm,
Andreas W. Reske,
Philipp Simon,
Hans-Bernd F. Hopf,
Michael Schuetz,
Thomas Baltus,
Metaxia N. Papanikolaou,
Theonymfi G. Papavasilopoulou,
Giannis A. Zacharas,
Vasilis Ourailogloy,
Eleni K. Mouloudi,
Eleni V. Massa,
Eva O. Nagy,
Electra E. Stamou,
Ellada V. Kiourtzieva,
Marina A. Oikonomou,
Luis E. Avila,
Cesar A. Cortez,
Johanna E. Citalán,
Sameer A. Jog,
Safal D. Sable,
Bhagyesh Shah,
Mohan Gurjar,
Arvind K. Baronia,
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Venkatapura J. Ramesh,
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Ramesh Unnikrishnan,
Subhal B. Dixit,
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Nagarajan Ramakrishnan,
Vallish K. Bhardwaj,
Heera L. Mahto,
Sudha V. Sagar,
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Deeban Ganesan,
Seyed Mohammadreza Hashemian,
Hamidreza Jamaati,
Farshad Heidari,
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Karl M. Knapman,
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Colin S. Black,
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Wahid Altaf,
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Savino Spadaro,
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Manuel Todeschini,
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Rossini Abbie B. Pasanting-Lim,
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Pawel Andruszkiewicz,
Karina Jakubowska,
Cristina M. Cox,
António M. Alvarez,
Bruno S. Oliveira,
Gustavo M. Montanha,
Nelson C. Barros,
Carlos S. Pereira,
António M. Messias,
Jorge M. Monteiro,
Ana M. Araujo,
Nuno T. Catorze,
Susan M. Marum,
Maria J. Bouw,
Rui M. Gomes,
Vania A. Brito,
Silvia Castro,
Joana M. Estilita,
Filipa M. Barros,
Isabel M. Serra,
Aurelia M. Martinho,
Dana R. Tomescu,
Alexandra Marcu,
Ovidiu H. Bedreag,
Marius Papurica,
Dan E. Corneci,
Silvius Ioan Negoita,
Evgeny Grigoriev,
Alexey I. Gritsan,
Andrey A. Gazenkampf,
Ghaleb Almekhlafi,
Mohamad M. Albarrak,
Ghanem M. Mustafa,
Khalid A. Maghrabi,
Nawal Salahuddin,
Tharwat M. Aisa,
Ahmed S. Al Jabbary,
Edgardo Tabhan,
Yaseen M. Arabi,
Olivia A. Trinidad,
Hasan M. Al Dorzi,
Edgardo E. Tabhan,
Stefan Bolon,
Oliver Smith,
Jordi Mancebo,
Hernan Aguirre-Bermeo,
Juan C. Lopez-Delgado,
Francisco Esteve,
Gemma Rialp,
Catalina Forteza,
Candelaria De Haro,
Antonio Artigas,
Guillermo M. Albaiceta,
Sara De Cima-Iglesias,
Leticia Seoane-Quiroga,
Alexandra Ceniceros-Barros,
Antonio L. Ruiz-Aguilar,
Luis M. Claraco-Vega,
Juan Alfonso Soler,
Maria del Carmen Lorente,
Cecilia Hermosa,
Federico Gordo,
Miryam Prieto-González,
Juan B. López-Messa,
Manuel P. Perez,
Cesar P. Pere,
Raquel Montoiro Allue,
Ferran Roche-Campo,
Marcos Ibañez-Santacruz,
Susana Temprano,
Maria C. Pintado,
Raul De Pablo,
Pilar Ricart Aroa Gómez,
Silvia Rodriguez Ruiz,
Silvia Iglesias Moles,
Mª Teresa Jurado,
Alfons Arizmendi,
Enrique A. Piacentini,
Nieves Franco,
Teresa Honrubia,
Meisy Perez Cheng,
Elena Perez Losada,
Javier Blanco,
Luis J. Yuste,
Cecilia Carbayo-Gorriz,
Francisca G. Cazorla-Barranquero,
Javier G. Alonso,
Rosa S. Alda,
Ángela Algaba,
Gonzalo Navarro,
Enrique Cereijo,
Esther Diaz-Rodriguez,
Diego Pastor Marcos,
Laura Alvarez Montero,
Luis Herrera Para,
Roberto Jimenez Sanchez,
Miguel Angel Blasco Navalpotro,
Ricardo Diaz Abad,
Raquel Montiel González,
Dácil Parrilla Toribio,
Alejandro G. Castro,
Maria Jose D. Artiga,
Oscar Penuelas,
Tomas P. Roser,
Moreno F. Olga,
Elena Gallego Curto,
Rocío Manzano Sánchez,
Vallverdu P. Imma,
Garcia M. Elisabet,
Laura Claverias,
Monica Magret,
Ana M. Pellicer,
Lucia L. Rodriguez,
Jesús Sánchez-Ballesteros,
Ángela González-Salamanca,
Antonio G. Jimenez,
Francisco P. Huerta,
Juan Carlos J. Sotillo Diaz,
Esther Bermejo Lopez,
David D. Llinares Moya,
Alec A. Tallet Alfonso,
Palazon Sanchez Eugenio Luis,
Palazon Sanchez Cesar,
Sánchez I. Rafael,
Corcoles G. Virgilio,
Noelia N. Recio,
Richard O. Adamsson,
Christian C. Rylander,
Bernhard Holzgraefe,
Lars M. Broman,
Joanna Wessbergh,
Linnea Persson,
Fredrik Schiöler,
Hans Kedelv,
Anna Oscarsson Tibblin,
Henrik Appelberg,
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Johan Helleberg,
Karin E. Eriksson,
Rita Glietsch,
Niklas Larsson,
Ingela Nygren,
Silvia L. Nunes,
Anna-Karin Morin,
Thomas Kander,
Anne Adolfsson,
Hervé O. Zender,
Corinne Leemann-Refondini,
Souheil Elatrous,
Slaheddine Bouchoucha,
Imed Chouchene,
Islem Ouanes,
Asma Ben Souissi,
Salma Kamoun,
Oktay Demirkiran,
Mustafa Aker,
Emre Erbabacan,
Ilkay Ceylan,
Nermin Kelebek Girgin,
Menekse Ozcelik,
Necmettin Ünal,
Basak Ceyda Meco,
Onat O. Akyol,
Suleyman S. Derman,
Barry Kennedy,
Ken Parhar,
Latha Srinivasa,
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Phil Hopkins,
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Christine Brown,
Andre Vercueil,
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Sally K. Humphreys,
Andrew Ferguson,
Raymond Mckee,
Ashok S. Raj,
Danielle A. Fawkes,
Philip Watt,
Linda Twohey,
Rajeev R. Jha Matthew Thomas,
Alex Morton,
Varsha Kadaba,
Mark J. Smith,
Anil P. Hormis,
Santhana G. Kannan,
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Henrik Reschreiter,
Julie Camsooksai,
Alek Kumar,
Szabolcs Rugonfalvi,
Christopher Nutt,
Orla Oneill,
Colette Seasman,
Ged Dempsey,
Christopher J. Scott,
Helen E. Ellis,
Stuart Mckechnie,
Paula J. Hutton,
Nora N. Di Tomasso,
Michela N. Vitale,
Ruth O. Griffin,
Michael N. Dean,
Julius H. Cranshaw,
Emma L. Willett,
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Sarah Gillis,
Peter Csabi,
Rosaleen Macfadyen,
Heidi Dawson,
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Alexandra J. Williams,
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Laura Ortiz-Ruiz De Gordoa,
Jon Bramall,
Sophie Symmonds,
Simon K. Chau,
Tim Wenham,
Tamas Szakmany,
Piroska Toth-Tarsoly,
Katie H. Mccalman,
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Lorraine Stephenson,
Thomas Collyer,
Rhiannon Chapman,
Raphael Cooper,
Russell M. Allan,
Malcolm Sim,
David W. Wrathall,
Donald A. Irvine,
Kim S. Zantua,
John C. Adams,
Andrew J. Burtenshaw,
Gareth P. Sellors,
Ingeborg D. Welters,
Karen E. Williams,
Robert J. Hessell,
Matthew G. Oldroyd,
Ceri E. Battle,
Suresh Pillai,
Istvan Kajtor,
Mageswaran Sivashanmugave,
Sinead C. Okane,
Adrian Donnelly,
Aniko D. Frigyik,
Jon P. Careless,
Martin M. May,
Richard Stewart,
T. John Trinder,
Samantha J. Hagan,
Matt P. Wise,
Jade M. Cole,
Caroline C. MacFie,
Anna T. Dowling,
Edgardo Nuñez,
Gustavo Pittini,
Ruben Rodriguez,
María C. Imperio,
Cristina Santos,
Ana G. França,
Alejandro Ebeid,
Alberto Deicas,
Carolina Serra,
Aditya Uppalapati,
Ghassan Kamel,
Valerie M. Banner-Goodspeed,
Jeremy R. Beitler,
Satyanarayana Reddy Mukkera,
Shreedhar Kulkarni,
Jarone Lee,
Tomaz Mesar,
John O. Shinn Iii,
Dina Gomaa,
Christopher Tainter,
R. Adams Cowley,
Dale J. Yeatts,
Jessica Warren,
Michael J. Lanspa,
Russel R. Miller,
Colin K. Grissom,
Samuel M. Brown,
Philippe R. Bauer,
Ryan J. Gosselin,
Barrett T. Kitch,
Jason E. Cohen,
Scott H. Beegle,
Renaud M. Gueret,
Aiman Tulaimat,
Shazia Choudry,
William Stigler,
Hitesh Batra,
Nidhi G. Huff,
Keith D. Lamb,
Trevor W. Oetting,
Nicholas M. Mohr,
Claine Judy,
Shigeki Saito,
Fayez M. Kheir,
Adam B. Schlichting,
Angela Delsing,
Mary Elmasri,
Daniel R. Crouch,
Dina Ismail,
Thomas C. Blakeman,
Kyle R. Dreyer,
Rebecca M. Baron,
Carolina Quintana Grijalba,
Peter C. Hou,
Raghu Seethala,
Imo Aisiku,
Galen Henderson,
Gyorgy Frendl,
Sen-Kuang Hou,
Robert L. Owens,
Ashley Schomer,
Vesna Bumbasirevic,
Bojan Jovanovic,
Maja Surbatovic,
Milic Veljovic
,
John G. Laffey,
Giacomo Bellani,
Carolyn S. Calfee,
Pratik Sinha,
Fernando Rios,
Frank Van Haren,
T. Sottiaux,
Fredy S. Lora,
Luciano C. Azevedo,
P. Depuydt,
Eddy Fan,
Guillermo Bugedo,
Haibo Qiu,
Marcos Gonzalez,
Juan Silesky,
Vladimir Cerny,
Jonas Nielsen,
Manuel Jibaja,
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Milic Veljovic
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