The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4 / UL5 Transcripts
Journal article published in 2021 by
Ana Cristina Gonzalez-Perez 
,
Markus Stempel ,
Emanuel Wyler,
Christian Urban,
Antonio Piras,
Thomas Hennig ,
Sabina Ganskih,
Yuanjie Wei,
Albert Heim ,
Markus Landthaler,
Andreas Pichlmair,
Lars Dölken,
Mathias Munschauer,
Florian Erhard,
Melanie M. Brinkmann
,
Markus Stempel ,
Emanuel Wyler,
Christian Urban,
Antonio Piras,
Thomas Hennig ,
Sabina Ganskih,
Yuanjie Wei,
Albert Heim ,
Markus Landthaler,
Andreas Pichlmair,
Lars Dölken,
Mathias Munschauer,
Florian Erhard,
Melanie M. Brinkmann
This paper is made freely available by the publisher.
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Abstract
Viral infections have a large impact on society, leading to major human and economic losses and even global instability. So far, many viral infections, including human cytomegalovirus (HCMV) infection, are treated with a small repertoire of drugs, often accompanied by the occurrence of resistant mutants.