Published in
American Association for the Advancement of Science, Science Immunology, 67(7), 2022
DOI: 10.1126/sciimmunol.abi6899
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A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors
Journal article published in 2022 by
Diyuan Xue 
,
Benjamin Moon ,
Jing Liao ,
Jingya Guo,
Zhuangzhi Zou,
Yanfei Han ,
Shuaishuai Cao,
Yang Wang ,
Yang-Xin Fu ,
Hua Peng
,
Benjamin Moon ,
Jing Liao ,
Jingya Guo,
Zhuangzhi Zou,
Yanfei Han ,
Shuaishuai Cao,
Yang Wang ,
Yang-Xin Fu ,
Hua Peng
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Abstract
A tumor-specific pro-IL-12 rejuvenated preexisting TILs to induce tumor growth delay without inducing systemic toxicity.