Published in
National Academy of Sciences, Proceedings of the National Academy of Sciences, 51(118), 2021
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Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism
Journal article published in 2021 by
Jelte van der Vaart,
Lynn Bosmans,
Stijn F. Sijbesma,
Kèvin Knoops,
Willine J. van de Wetering 
,
Henny G. Otten,
Harry Begthel,
Inne H. M. Borel Rinkes,
Jeroen Korving,
Eef G. W. M. Lentjes,
Carmen Lopez-Iglesias,
Peter J. Peters,
Hanneke M. van Santen,
Menno R. Vriens,
Hans Clevers
,
Henny G. Otten,
Harry Begthel,
Inne H. M. Borel Rinkes,
Jeroen Korving,
Eef G. W. M. Lentjes,
Carmen Lopez-Iglesias,
Peter J. Peters,
Hanneke M. van Santen,
Menno R. Vriens,
Hans Clevers
This paper is made freely available by the publisher.
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Abstract
Significance The thyroid is essential for maintaining systemic homeostasis by regulating thyroid hormone concentrations in the bloodstream. This study describes an organoid-based model system to study mouse and human thyroid biology. Moreover, the study explores the potential of human organoids for modeling autoimmune disease, the anti-TSH receptor (TSHR) antibody-driven Graves’ hyperthyroidism.