Published in
American Association for the Advancement of Science, Science Translational Medicine, 622(13), 2021
DOI: 10.1126/scitranslmed.abe3947
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AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
Journal article published in 2021 by
Faten A. Sayed 
,
Lay Kodama ,
Li Fan ,
Gillian K. Carling ,
Joe C. Udeochu,
David Le ,
Qingyun Li ,
Lu Zhou,
Man Ying Wong,
Rose Horowitz ,
Pearly Ye,
Hansruedi Mathys ,
Minghui Wang ,
Xiang Niu ,
Linas Mazutis
and other authors.
,
Lay Kodama ,
Li Fan ,
Gillian K. Carling ,
Joe C. Udeochu,
David Le ,
Qingyun Li ,
Lu Zhou,
Man Ying Wong,
Rose Horowitz ,
Pearly Ye,
Hansruedi Mathys ,
Minghui Wang ,
Xiang Niu ,
Linas Mazutis
and other authors.
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Abstract
R47H- TREM2 mutation enhances AKT signaling in human AD microglia and mediates proinflammatory and synaptic toxicity in a tauopathy mouse model.