Coffee has a significant economic, social, and cultural impact on Brazilian society, generating jobs for thousands of Brazilians. Good management practices such as weed control have direct and indirect benefits on coffee yield and quality. Currently, there is an increase in the infestation rate of Digitaria insularis in coffee plantations due to chemical resistance to glyphosate. In the literature, the study of the combination of glyphosate with different herbicides has been investigated, aiming at improving the efficiency of the control of Digitaria insularis. The objective of this work was to evaluate the efficiency of control of the Digitaria insularis in a coffee farm using a combination of glyphosate with clethodim and phenoxaprope-p-ethyl. Trials were conducted in a commercial coffee farm in southern Minas Gerais in a field with a two-year-old cultivar IAC Catuaí 144. The experiment was conducted under a completely randomized design with five treatments and four replications, totaling 20 experimental plots. Thirty and ninety days after application, the plant numbers were counted and the visual analysis with the use of drones and the digital camera. The results show that the use of glyphosate alone was not efficient in the power of Digitaria insularis. The results show that the herbicide mixtures were efficient in the control.