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Published in

American Physiological Society, American Journal of Physiology - Gastrointestinal and Liver Physiology, 1(321), p. G18-G28, 2021

DOI: 10.1152/ajpgi.00408.2020

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Subclinical necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

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Data provided by SHERPA/RoMEO

Abstract

Necrotizing enterocolitis (NEC) and sepsis are common diseases in preterm infants. Many develop sepsis following an episode of suspected NEC, suggesting NEC as a predisposing factor for sepsis but mechanisms are unclear. Using preterm pigs as a model, now we show that subclinical NEC lesions, independent of clinical confounding factors, induces systemic immune suppression. The results may help to explain the increased risks of infection and sepsis in preterm infants with previous NEC diagnosis.