Published in
American Society for Microbiology, Journal of Clinical Microbiology, 8(59), 2021
DOI: 10.1128/jcm.00319-21
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Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests, and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum
,
Julia Gütling,
Johannes Wagener,
Thiên-Trí Lâm ,
Christoph Schoen,
Ulrich Vogel,
August Stich,
Florian Wedekink,
Jörg Wischhusen,
Thomas Kerkau,
Niklas Beyersdorf,
Silvana Klingler,
Simone Backes,
Lars Dölken,
Georg Gasteiger
and other authors.
Full text: Unavailable
Abstract
For the control of immunity in COVID-19 survivors and vaccinated subjects, there is an urgent need for reliable and rapid serological assays. Based on samples from 63 COVID-19 survivors up to 7 months after symptom onset, and on 50 serum samples taken before the beginning of the pandemic, we compared the performances of three commercial immunoassays for the detection of SARS-CoV-2 IgA and IgG antibodies (Euroimmun SARS-COV-2 IgA/IgG, Mikrogen recom Well SARS-CoV-2 IgA/IgG, and Serion ELISA agile SARS-CoV-2 IgA/IgG) and three rapid lateral flow (immunochromatographic) tests (Abbott PanBio COVID-19 IgG/IgM, Nadal COVID-19 IgG/IgM, and Cleartest Corona 2019-nCOV IgG/IgM) with a 50% plaque-reduction neutralization test (PRNT50) representing the gold standard.