Significance The western United States (WUS) has experienced a rapid increase of fire weather (as indicated by vapor pressure deficit, VPD) in recent decades, especially in the warm season. However, the extent to which an increase of VPD is due to natural variability or anthropogenic warming has been unclear. Our observation-based estimate suggests ∼one-third of the VPD trend is attributable to natural variability of atmospheric circulation, whereas ∼two-thirds is explained by anthropogenic warming. In addition, climate models attribute ∼90% of the VPD trend to anthropogenic warming. Both estimates suggest that anthropogenic warming is the main cause for increasing fire weather and provide a likely range for the true anthropogenic contribution to the WUS trend in VPD.