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National Academy of Sciences, Proceedings of the National Academy of Sciences, 29(118), 2021

DOI: 10.1073/pnas.2024853118

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Telomere dysfunction instigates inflammation in inflammatory bowel disease

Journal article published in 2021 by Deepavali Chakravarti, Rumi Lee ORCID, Asha S. Multani, Andrea Santoni, Zachery Keith ORCID, Wen-Hao Hsu, Kyle Chang ORCID, Laura Reyes, Asif Rashid, Jun Li, Jiexin Zhang ORCID, Chang-Jiun Wu ORCID, Hong Seok Shim ORCID, Krishna Chandra ORCID, Pingna Deng and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Inflammatory bowel disease (IBD) is a chronic debilitating condition with limited treatment options. Recently, we found that telomerase reactivation can ameliorate intestinal inflammation in a mouse model of IBD through the regulation of the YAP1/pro-IL-18 axis. This study aims to validate the therapeutic potential of this axis genetically and with the use of small molecule activators and inhibitors in the intestinal epithelium of IBD patients.